| Cat. No. |
Product Name |
Information |
| PC-24283 |
AM1476
5-HT2B inhibitor
|
AM1476 is a highly selective 5-HT2B receptor (5-HT2BR) inhibitor with IC50 of 5.8 nM, showed only low activity at the5-HT2AR (IC50 >10 000 nM) and 5-HT2CR. |
| PC-24197 |
AAZ-A-154
5-HT2R ligand
|
Zalsupindole (AAZ-A-154) is a potent, highly selective non-hallucinogenic psychLight competitive ligand/antagonist of 5-HT2A receptor (5-HT2AR), exhibits antidepressant-like effects. |
| PC-24117 |
Bretisilocin
5-HT2A agonist
|
Bretisilocin (GM-2505) is a potent, selective 5-HT2A receptor agonist with the EC50 of 5.54 nM. |
| PC-23306 |
Vilazodone
5-HT1A agonist, SSRI
|
Vilazodone (EMD68843, SB659746A) is a potent, dual 5-HT1A agonist and serotonin reuptake inhibitor (SSRI) with IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT. |
| PC-22530 |
RE104
5-HT2A agonist
|
Luvesilocin (RE104) is the prodrug of 4-OH-DiPT, a synthetic 5-hydroxytryptamine 2A receptor (5-HT2A receptor) agonist with Ki of 0.12 uM. |
| PC-22277 |
SB269970
5-HT7 antagonist
|
SB269970 (SB-269970) is a potent, selective 5-HT7 receptor antagonist with pKi of 8.9, >100-fold selective over other 5-HT receptors. |
| PC-21971 |
Bexicaserin
5-HT2C agonist
|
Bexicaserin (LP352) is a potent, highly selective, oral and centrally acting 5-HT2C receptor agonist with EC50 of 42 nM (Emax=112%), and Ki of 39 nM. |
| PC-21829 |
VU6047534
5-HT2B agonist
|
VU6047534 is a selective, peripherally restricted 5-HT2B partial agonist with IC50 of 480 nM in radioligand binding assays. |
| PC-21787 |
5-HT2A antagonist 11c
5-HT2A antagonist
|
5-HT2A antagonist 11c is a potent, selective, peripheral 5HT2A antagonist with IC50 of 14 nM. |
| PC-21121 |
SB-271046
5-HT6 antagonist
|
SB-271046 is a potent, selective and orally active 5-HT6 receptor antagonist, potently displaces [(3)H]-LSD and [(125)I]-SB-258585 from human 5-HT6 receptors recombinantly expressed in HeLa cells with pKi 8.92 and 9.09 respectively. |
| PC-20963 |
Pimavanserin
5-HT2A inverse agonist
|
Pimavanserin (ACP-103) is a potent, selective, orally active 5-HT2A receptor inverse agonist, competitively antagonizes the binding of [(3)H]ketanserin to heterologously expressed human 5-HT(2A) receptors with pKi of 9.3 in membranes and 9.70 in whole cells. |
| PC-20844 |
EMD386088
5-HT6 agonist
|
EMD386088 is a potent, selective 5-HT6 receptor agonist with EC50 of 1.0 nM. |
