| Cat. No. |
Product Name |
Information |
| PC-42654 |
Ketanserin tartrate
5-HT2A antagonist
|
Ketanserin tartrate (R41468 tartrate) is a high-affinity, non-selective antagonist of 5-HT2 receptor with Ki of 2-3 nM for 5-HT2A and 28 nM for 5-HT2C. |
| PC-42653 |
Ketanserin
5-HT2A antagonist
|
Ketanserin (R41468) is a high-affinity, non-selective antagonist of 5-HT2 receptor with Ki of 2-3 nM for 5-HT2A and 28 nM for 5-HT2C. |
| PC-45229 |
Ziprasidone hydrochloride monohydrate
D2/5-HT2A antagonist
|
Ziprasidone hydrochloride monohydrate (CP-88059) is a full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively. |
| PC-43963 |
Ziprasidone
D2/5-HT2A antagonist
|
Ziprasidone (CP 88059) is a full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively. |
| PC-26777 |
Trazodone
Antidepressant
|
Trazodone (AF-1161) is an antidepressant that inhibits reuptake of serotonin, causes adrenoreceptor subsensitivity, acts as a 5HT2a receptor antagonist and induces significant changes in 5-HT presynaptic receptor adrenoreceptors, also significantly blocks histamine (H1) and alpha1-adrenergic receptors. |
| PC-26749 |
BIMU8
5-HT4R agonist
|
BIMU8 (BIMU 8) is a potent and selective 5-HT4 receptor (5-HT4R) agonist with EC50 of 18 nM. |
| PC-26609 |
SB-656104A
5-HT7 antagonist
|
SB-656104A (SB-656104-A) is a potent, selective 5-HT7 receptor antagonist, potently inhibits [3H]-SB-269970 binding to the human cloned 5-HT7(a) (pKi=8.7) and 5-HT7(b) (pKi=8.5) receptor variants and the rat native receptor (pKi=8.8). |
| PC-26558 |
Tropisetron
5-HT3R antagonist
|
Tropisetron (SDZ-ICS-930) is a potent, orally active 5-HT3R antagonist (Ki=5.3 nM), also is a potent and selective α7 nicotinic partial agonist (EC50=1.3 uM). |
| PC-26505 |
Cyproheptadine
5-HT2A antagonist
|
Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist and histamine H1 receptor (HRH1) inverse agonist, promotes FOXO3 nuclear translocation and increases FOXO target genes while suppressing inflammation. |
| PC-26483 |
AG-670
NNMT inhibitor, 5-HT3 NAM
|
AG-670 (PU02) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with EC50 of 2.7 uM, also is a negative allosteric modulator (NAM) of 5-HT3 receptor with IC50 of 0.36 and 0.73 uM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively. |
| PC-26338 |
Lumocaserin hydrochloride
5-HT2C agonist
|
Lumocaserin hydrochloride is a potent, selective serotonin 2C receptor (5-HT2C receptor) agonist with EC50 of 11 nM (Emax=88%), with limited activity against 5-HT2B and 5-HT2A receptors. |
| PC-26337 |
Lumocaserin
5-HT2C agonist
|
Lumocaserin is a potent, selective serotonin 2C receptor (5-HT2C receptor) agonist with EC50 of 11 nM (Emax=88%), with limited activity against 5-HT2B and 5-HT2A receptors. |
