| Cat. No. |
Product Name |
Information |
| PC-24892 |
LY272015
5-HT2B antagonist
|
LY272015 hydrochloride is a potent, selective and orally bioactive 5-HT2B receptor (5-HT2BR) antagonist with IC50 of 0.26 nM. |
| PC-24891 |
MARY1
5-HT2B antagonist
|
MARY1 is potent, and selective 5-hydroxytryptamine 2B receptor (5-HT2BR) antagonist with Ki of 764 nM, induces mitochondrial biogenesis (MB) enhances mitochondrial function in the kidney. |
| PC-24876 |
Palonosetron hydrochloride
5-HT3 antagonist
|
Palonosetron (RS 25259-197) is a potent, selective 5-HT3 receptor antagonist with pKi value of 10.4, >10,000-fold selective over 5-HT1A/1D/2A/2C receptors. |
| PC-24462 |
NLX-266
5-HT1A agonist
|
NLX-266 is a potent, selective, orally available and metabolically stable ERK1/2-biased 5-HT1A receptor agonist with binding pKi of 10.35, >1000-fold selective over adrenergic α1 and dopaminergic D2 receptors. |
| PC-24324 |
MW073
5-HT2bR inhibitor
|
MW073 is a highly selective and orally bioavailable inhibitor of 5-HT2b receptor (5-HT2bR) with binding IC50 of 70 nM. |
| PC-24221 |
PUC-55
5-HT6R antagonist
|
PUC-10 is a selective 5-HT6 receptor antagonist high binding affinity (Ki=37.5 nM), induces autophagy in the neuroblastoma SH-SY5Y cell line by inhibiting the mTOR pathway. |
| PC-24220 |
PUC-10
5-HT6R antagonist
|
PUC-10 is a selective 5-HT6 receptor antagonist high binding affinity (Ki=14.6 nM) and IC50 of 32 nM in calcium mobilisation functional assay, induces mTOR-dependent autophagy. |
| PC-24116 |
Bretisilocin hydrochloride
5-HT2A agonist
|
Bretisilocin hydrochloride is a potent, selective 5-HT2A receptor agonist with the EC50 of 5.54 nM. |
| PC-23913 |
ST1936
5-HT6 agonist
|
ST1936 is a potent, selective 5-HT6 receptor agonist with Ki of 13 nM, >10-fold selectivity over 5-HT7 and 5-HT2B receptors. |
| PC-23513 |
LY266097 hydrochloride
5-HT2B antagonist
|
LY266097 hydrochloride is a potent, selective 5-HT2B receptor antagonist with pKi value of 9.8, >100-fold selective over 5-HT2A and 5-HT2C. |
| PC-23512 |
MRS8209
5-HT2B antagonist
|
MRS8209 is a potent, peripheral subtype-selective 5-HT2B serotonin receptor antagonist with Ki of 4.27 nM (human 5-HT2B), shows reduced affinity at the m5-HT2BR and r5-HT2BR (100-fold and 10-fold). |
| PC-23422 |
Aripiprazole
Dopamine agonist
|
Aripiprazole (OPC-14597) is an atypical antipsychotic, and potent and high-affinity dopamine D2 receptor (D2R) partial agonist, also is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. |
