| Cat. No. |
Product Name |
Information |
| PC-28211 |
Cisapride
hERG blocker, 5-HT4 agonist
|
Cisapride (R 51619) is a potent, selective and orally active 5-HT4 receptor agonist with EC50 of 140 nM, is also an hERG potassium channel blocker with IC50 of 9.4 nM, inhibits voltage-dependent K(+) (Kv) channels using freshly isolated smooth muscle cells. |
| PC-28210 |
Tiapride
Dopamine D2/D3 receptor antagonist
|
Tiapride is a potent, selective dopamine D2/D3 receptor antagonist with IC50 of 110-320 nM and 180 nM, respectively, shows antidyskinetic activity and anxiolytic activity. |
| PC-28209 |
Tiapride hydrochloride
Dopamine D2/D3 receptor antagonist
|
Tiapride hydrochloride is a potent, selective dopamine D2/D3 receptor antagonist with IC50 of 110-320 nM and 180 nM, respectively, shows antidyskinetic activity and anxiolytic activity. |
| PC-28206 |
AM1476 hydrochloride
5-HT2B inhibitor
|
AM1476 hydrochloride is a highly selective 5-HT2B receptor (5-HT2BR) inhibitor with IC50 of 5.8 nM, showed only low activity at the5-HT2AR (IC50 >10 000 nM) and 5-HT2CR. |
| PC-27960 |
Flibanserin
5-HT1A agonist, 5-HT2A antagonist
|
Flibanserin (BIMT-17, BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki of 1 nM and 49 nM, respectively, shows anti-depression and anti-anxiety effects. |
| PC-27286 |
Alverine citrate
5-HT1A antagonist
|
Alverine citrate is a synthetic derivative of papaverine and selective 5-HT1A receptor antagonist with IC50 of 101 nM, is an antispasmodic agent to alleviate smooth muscle spasms. |
| PC-27115 |
PRX-08066
5-HT2B antagonist
|
PRX-08066 is a potent, selective 5-HT2B receptor (5-HT2BR) antagonist with Ki of 3.4 nM, causes selective vasodilation of pulmonary arteries. |
| PC-27114 |
SB200646
5-HT2B/2C antagonist
|
SB200646 (SB-200646A) is a potent, selective and orally active 5-HT2B/2C receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively, shows electrophysiological and anxiolytic properties. |
| PC-27113 |
YM348
5-HT2C agonist
|
YM348 is a potent, selective and orally active 5-HT2C receptor agonist with Ki of 0.89 nM for cloned human 5-HT(2C) receptor. |
| PC-27112 |
AL-34662
5-HT2A agonist
|
AL-34662 is a potent, selective, and efficacious serotonin-2 (5-HT2) receptor agonist with binding IC50 of 0.8-1.5 nM for rat and human 5-HT2 receptors, and 3-14.5 nM for cloned human 5-HT2A-C receptors. |
| PC-27111 |
RS-127445 hydrochloride
5-HT2B antagonist
|
RS-127445 hydrochloride is a potent, selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with pKi of 9.5, 1,000 fold selectivity over numerous other receptor and ion channel binding sites. |
| PC-27110 |
RS-127445
5-HT2B antagonist
|
RS-127445 (MT-500, RS-127445) is a potent, selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with pKi of 9.5, 1,000 fold selectivity over numerous other receptor and ion channel binding sites. |
