| Cat. No. |
Product Name |
Information |
| PC-20096 |
ACT-777991
CXCR3 inhibitor
|
ACT-777991 (ACT777991) is a highly potent and selective CXCR3 antagonist with IC50 of 33 nM. |
| PC-49464 |
RPT193
CCR4 inhibitor
|
RPT193 (RPT-193) is a highly potent, selective and orally active CCR4 antagonist, inhibits CCL22- induces human Th2 chemotaxis with IC50 of 370 nM. |
| PC-49306 |
MR120
CCR6 inhibitor
|
MR120 (CCR6 antagonist 1b) is a potent, selective CCR6 antagonist, disrupts the CCL20-induced chemotaxis of CCR6+CD4+ T cells. |
| PC-49202 |
AMD3465
CXCR4 antagonist
|
AMD3465 (AMD 3465) is a potent, selective monomacrocyclic CXCR4 antagonist with IC50 of 0.75 nM for inhibition of 12G5 mAb binding to CXCR4, dose-dependently inhibits CXCL12 binding in SupT1 cells with IC50 of 18 nM. |
| PC-49201 |
BPRCX714
CXCR4 antagonist
|
BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM. |
| PC-49200 |
BPRCX807
CXCR4 antagonist
|
BPRCX807 (BPRCX-807) is a highly selective and potent CXCR4 antagonist with binding IC50 of 40.4 nM and EC50 of 48.1 nM for cell-mobility activity in the chemotaxis assays, inhibits CXCL12-mediated cell signaling pathway. |
| PC-49142 |
BMS-753426
CCR2 inhibitor
|
BMS-753426 is a potent, selective and orally bioavailable antagonist of CCR2 with binding IC50 of 2.7 nM, 30-fold selectivity over CCR5. |
| PC-38499 |
Cenicriviroc
CCR2/CCR5 inhibitor
|
Cenicriviroc (TAK-652, TBR-652) is a potent, selective, orally active, dual CCR2/CCR5 antagonist with IC50 of 5.9/0.29 nM, inhibits both HIV-1 and HIV-2 and prevents viral cellular entry. |
| PC-38366 |
Lazucirnon
CCR3 antagonist
|
Lazucirnon (KST4290, ALK4290) is a small molecule, orally active inhibitor against CCR3, the natural receptor for chemokine eotaxin, decreases inflammatory cytokines in preclinical models. |
| PC-73268 |
NBI-74330
CXCR3 antagonist
|
NBI-74330 is a potent, selective CXC chemokine receptor 3 (CXCR3) antagonist, inhibits [(125)I]CXCL10 and [(125)I]CXCL11 specific binding with Ki of 1.5 and 2.3 nM, respectively. |
| PC-73261 |
BMS-570520
CCR3 antagonist
|
BMS-570520 is a potent, selective CCR3 antagonist with IC50 of 1.9 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.068 nM. |
| PC-73260 |
DPC168
CCR3 antagonist
|
DPC168 (DPC-168) is a highly potent, selective CC chemokine receptor-3 (CCR3) antagonist with IC50 of 2.0 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.034 nM. |
