| Cat. No. |
Product Name |
Information |
| PC-26546 |
FB231
Parkin activator
|
FB231 is a small molecule enhancer / activator of Parkin E3 ubiquitin ligase (PARK2) activity with EC50 of 6.75 uM in in vitro ubiquitination assay. |
| PC-26528 |
CLEO4-88
GID4 binder, ACAA1 inhibitor
|
CLEO4-88 is a molecular glue binder of CTLH E3 ligase substrate adaptor GID4 with KD of 5.6 uM, promotes GID4 interaction with the peroxisomal thiolase protein ACAA1 with EC50 of 12.5 nM in HTRF assays, inhibits the catalytic activity of ACAA1. |
| PC-25638 |
XMU-MP-10 TFA salt
NEDD4 inhibitor
|
XMU-MP-10 TFA salt is a potent, specific, high-affinity inhibitor of HECT-type E3 ubiquitin ligase NEDD4 with MST KD of 43.92 nM, targets the HECT domain of NEDD4, significantly and selectively inhibits NEDD4 auto-ubiquitination. |
| PC-25637 |
XMU-MP-10
NEDD4 inhibitor
|
XMU-MP-10 is a potent, specific, high-affinity inhibitor of HECT-type E3 ubiquitin ligase NEDD4 with MST KD of 43.92 nM, targets the HECT domain of NEDD4, significantly and selectively inhibits NEDD4 auto-ubiquitination. |
| PC-25377 |
A5-MMC17
FBW7 modulator
|
A5-MMC17 is a specific, small molecule allosteric modulator of FBW7 E3 ligase with MST Kd of 45 uM, targets FBW7-pocket G, induces proteasome- and Cullin-RING-dependent c-MYC and c-JUN degradation in cells. |
| PC-24933 |
DDO-4033
SPOP inhibitor
|
DDO-4033 is a potent, selective E3 ligase speckle-type POZ protein (SPOP) inhibitor with IC50 of 16.48 uM, binds to SPOP-MATH with Kd of 15.1 uM in MST assay. |
| PC-24401 |
GH501
Skp1-Skp2 inhibitor
|
GH501 is a small molecule inhibitor of Skp1-Skp2 interaction, may bind Skp1 and disrupts the physical interaction between Skp1 and S-phase kinase-associated protein 2 (Skp2) within the Skp1-Cullin1-F-box protein ubiquitin ligase complexes (SCF). |
| PC-23661 |
Y043-4427
DTX2 inhibitor
|
Y043-4427 (mDTX2i, C22H24N4O2) is a potent small molecule inhibitor of Deltex E3 ubiquitin ligase 2 (DTX2) with IC50 of 30.83 uM in Hepa1-6 cells. |
| PC-23528 |
iBFAR2
BFAR inhibitor
|
iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice. |
| PC-22133 |
LS-102
Synoviolin inhibitor
|
LS-102 is a selective small molecule inhibitor of E3 ubiquitin ligase Synoviolin (SYVN1), inhibits the autoubiquitination of synoviolin with IC50 of 35 uM. |
| PC-21791 |
MN714
SOCS2 inhibitor
|
MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2). |
| PC-21790 |
MN551
SOCS2 inhibitor
|
MN551 is a Cys111-specific, covalent ligand targeting the E3 ligase SOCS2 with ITC Ki value of 2.2 uM, blocks recruitment of cellular SOCS2 protein to its native substrate. |
