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Cat. No. Product Name Information
PC-20292

OICR-8268

DCAF1 ligand

OICR-8268 (OICR8268) is a highly potent, reversible, small molecule ligand of DCAF1 (Vpr binding protein) with SPR KD of 38 nM, a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP).
PC-49196

BC18630 free base

DCAF7 inhibitor

BC18630 free base (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays.
PC-49194

BC18813

DCAF7 inhibitor

BC18813 (BC 18813) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 48 nM in cell-based assays.
PC-49193

BC18630

DCAF7 inhibitor

BC18630 (BC 18630) is a small molecule inhibitor of the E3 ubiquitin ligase subunit DCAF7, potently inhibits SARS-CoV-2 infection with IC50 of 39 nM in cell-based assays.
PC-72861

BIO-2007817

Parkin E3 ligase modulator

BIO-2007817 is a small-molecule positive allosteric modulator of Parkin E3 ligase with EC50 of 0.17 uM (TR-FRET).
PC-72548

KH-4-43

E3 CRL4 inhibitor

KH-4-43 is a small moelcule E3 CRL4 inhibitor and exhibits antitumor potential, directly and selectively binds to the purified E3 ROC1-CUL4A CTD complex with Kd of 83 nM.
PC-72478

BC1618

Fbxo48 inhibitor

BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels.
PC-38305

PRC1 inhibitor RB-3

PRC1 inhibitor

PRC1 inhibitor RB-3 (RB-3) is a small molecule PRC1 inhibitor that directly bind to RING1B-BMI1 (KD=2.8 uM), the heterodimeric complex constituting the E3 ligase activity of PRC1.
PC-38239

MS.001

CHIP inhibitor

MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
PC-38107

Myomed-946

MuRF1 (TRIM63) inhibitor

MyoMed-946 is a small moelcule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.
PC-38106

MyoMed-205

MuRF1 (TRIM63) inhibitor

MyoMed-205 is a small molecule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.
PC-35959

HOIPIN-8

HOIP inhibitor

HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.

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