| Cat. No. |
Product Name |
Information |
| PC-25333 |
RANKL inhibitor 19u
RANKL inhibitor
|
RANKL inhibitor 19u is a potent small molecule inhibitor of RANKL-RANK protein interaction with BLI KD of 7.6 uM (RANKL), inhibits RANKL-induced TRAP activity in RAW264.7 cells with IC50 of 0.07 uM. |
| PC-21743 |
JSH-23
NF-κB inhibitor
|
JSH-23 is a small molecule NF-κB inhibitor, inhibits NF-κB transcriptional activity with IC50 of 7.1 uM in LPS-stimulated macrophages RAW 264.7. |
| PC-21026 |
AS2676293
RANKL inhibitor
|
AS2676293 (AS 2676293) is an orally active small-molecule receptor activator of nuclear factor-κB ligand (RANKL) inhibitor, inhibits RANKL-induced osteoclastogenesis using RAW264 cells with IC50 of 0.19 uM. |
| PC-49360 |
IT848
NF-κB inhibitor
|
IT848 (IT-848) is a potent and specific small molecule NF-κB inhibitor, decreases the affinity of NF-κB all five subunits (Rel A, Rel B, c-Rel, p50 and p52) to their DNA binding sites and disrupts downstream biological events. |
| PC-49334 |
sRANKL inhibitor S3-15
sRANKL inhibitor
|
sRANKL inhibitor S3-15 is a highly potent, orally active inhibitor of soluble RANKL, selectively interrupt soluble RANKL-RANK interaction and without interfering with the membrane RANKL-RANK interaction, shows potent osteoclast inhibition effect with IC50 of 0.19 uM in vitro. |
| PC-49234 |
Y1693
RANKL inhibitor
|
Y1693 is a potent, orally active small-molecule RANKL inhibitor, effectively prevents RANKL-induced osteoclastogenesis (89% inhibition at 1 uM) and bone resorption. |
| PC-47045 |
CRL1101
RelA inhibitor
|
CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells. |
| PC-47044 |
DHMEQ
NF-κB inhibitor
|
DHMEQ (dehydroxymethylepoxyquinomicin) is an NF-κB inhibitor, inhibits TNF-α-induced activation of NF-κB, and inhibits the TNF-α-induced nuclear accumulation of p65, a component of NF-κB. |
| PC-38805 |
ML236
NF-κB inhibitor
|
ML236 is a potent, B-cell specific NF-κB inhibitor with IC50 of 35 nM, selective for the NF-κB pathway induced by PKC activators (phorbol myristic acetate/ionomycin) and selective for B-cells. |
| PC-38798 |
ML029
NF-κB inhibitor
|
ML029 is a potent and selective probe inhibiting the PKC-initiated NF-kappaB pathway with IC50 of 67 nM. |
| PC-38514 |
WAY-169916
NF-kB inhibitor
|
WAY-169916 is an orally active pathway-selective estrogen receptor (ER) ligand, inhibiting NF-kB transcriptional activity (IC50=93 nM), but is devoid of conventional estrogenic activity. |
| PC-73379 |
AS2690168 free base
RANKL inhibitor
|
AS2690168 is a novel orally available, selective RANKL signal transduction inhibitor, reduces TRAP staining of sRANKL-stimulated RAW264 cells with IC50 of 0.28 uM, suppresses RANKL-induced osteoclastogenesis. |
