| Cat. No. |
Product Name |
Information |
| PC-25953 |
SK2 channel activator Compound 4
SK2 channel activator
|
SK2 channel activator Compound 4 is a potent, selective activator of small conductance calcium-activated potassium channel 2 (SK2), dose-dependently increases SK2 current in the presence of 2 µM intracellular Ca2+. |
| PC-25952 |
SK2 channel inhibitor Compound 1
SK2 channel inhibitor
|
SK2 channel inhibitor Compound 1 is a potent, selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2) with IC50 of 69 nM, with 10-fold reduced potency for SK4 (IC50=660 nM), has high selectivity over other ion channels tested including hERG, Nav1.5, KCNQ1, and Cav1.2. |
| PC-25626 |
ONO-7927846
TERK inhibitor
|
ONO-7927846 (VU6024391) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 110 nM and 290 nM for human TREK-1 and TREK-2 in thallium flux assays respectively. |
| PC-25625 |
ONO-9517601
TERK inhibitor
|
ONO-9517601 (VU6022856) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 67 nM and 230 nM for human TREK-1 and TREK-2 in thallium flux assays respectively. |
| PC-25574 |
VU6080824
Kir2.1 inhibitor
|
VU6080824 is a potent, selective inhibitor of the inward-rectifier potassium channel Kir2.1 with IC50 of 5.9 uM in Kir2.1 thallium flux assays, selective relative to Kir1.1 and Kir4.1 up to 10 uM. |
| PC-25544 |
VU6032735
SLO3 inhibitor
|
VU6032735 is a highly potent, subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 of 165 nM (hSLO3), 172-fold selective over hERG. |
| PC-25468 |
DCY1020
TMEM175 agonist
|
DCY1020 is a potent, specific small molecule agonist of transmembrane protein 175 (TMEM175) with EC50 of 3.7 uM, binds to TMEM175 with SPR KD of 8.3 uM. |
| PC-25451 |
IDOR-1104-0086
Kv7.2/3 activator
|
IDOR-1104-0086 is a potent activator of Kv7.2/3 channels with EC50 of 192 nM in HEK293 cells stably expressing hKv7.2/3 heterotetramers (Emax=94%), and EC50 of 321 nM for hKv7.3/5 heterotetramers (Emax=85%). |
| PC-25403 |
VU625
AeKir1 inhibitor
|
VU625 (VU0077625) is a potent and selective inhibitor of Aedes aegypti Kir1 (AeKir1) channel with IC50 of 96.8 nM in patch clamp electrophysiology experiments of HEK293 cells, selective for AeKir1 over mammalian Kir channels and AeKir2B channel. |
| PC-24784 |
Zj7923
Kv2.1
|
Zj7923 is a potent, selective voltage-dependent potassium channel Kv2.1 blocker with IC50 of 0.12 uM, >130-fold selectivity for Kv2.1 over Kv1.5, Kv3.1, hERG, TREK-1. |
| PC-24770 |
LPS2336
TREK-1 activator
|
LPS2336 is a potent TREK-1 (K2P2.1) activator with EC50 of 11.76 uM, LPS2336 (50 uM) increases the mean current density recorded at 0 mV in HEK-hTREK-1 cells by 10.77-fold using patch clamp assays. |
| PC-24598 |
TKIM
TREK-1 inhibitor
|
TKIM is a small molecule TREK-1 channel inhibitor with an IC50 of 2.96 μM, binds to the pocket of the intermediate (IM) state of TREK-1. |
