| Cat. No. |
Product Name |
Information |
| PC-26171 |
Apamin TFA
SK channel inhibitor
|
Apamin (Apamine) TFA is a peptide neurotoxin found in apitoxin and selective small conductance Ca(2+)-activated K(+) (SK(Ca)) channel blocker, exhibits anti-inflammatory and anti-fibrotic activity. |
| PC-26170 |
Apamin
SK channel inhibitor
|
Apamin (Apamine) is a peptide neurotoxin found in apitoxin and selective small conductance Ca(2+)-activated K(+) (SK(Ca)) channel blocker, exhibits anti-inflammatory and anti-fibrotic activity. |
| PC-26105 |
ICA73
KCNQ2 activator
|
ICA‐069673 (ICA73) is a selective activator of KCNQ2 potassium channel (Kv7.2), acts within the voltage-sensor domain (VSD), shows selective effects on KCNQ2 over KCNQ3. |
| PC-26104 |
ztz240
KCNQ2 activator
|
ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels. |
| PC-26103 |
E0714
Kv7.2 agonist
|
E0714 (E-0714) is a potent, specific agonist of Kv7.2 potassium channel (KCNQ2) with EC50 of 1.9 uM and 0.021 uM for Kv7.2 and Kv7.2/7.3 currents, with no significant activation of Kv7.1/7.3/7.4/7.5. |
| PC-25953 |
SK2 channel activator Compound 4
SK2 channel activator
|
SK2 channel activator Compound 4 is a potent, selective activator of small conductance calcium-activated potassium channel 2 (SK2), dose-dependently increases SK2 current in the presence of 2 µM intracellular Ca2+. |
| PC-25952 |
SK2 channel inhibitor Compound 1
SK2 channel inhibitor
|
SK2 channel inhibitor Compound 1 is a potent, selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2) with IC50 of 69 nM, with 10-fold reduced potency for SK4 (IC50=660 nM), has high selectivity over other ion channels tested including hERG, Nav1.5, KCNQ1, and Cav1.2. |
| PC-25626 |
ONO-7927846
TERK inhibitor
|
ONO-7927846 (VU6024391) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 110 nM and 290 nM for human TREK-1 and TREK-2 in thallium flux assays respectively. |
| PC-25625 |
ONO-9517601
TERK inhibitor
|
ONO-9517601 (VU6022856) is a selective and CNS penetrant TWIK-related K+ channels (TREK) inhibitor with IC50 of 67 nM and 230 nM for human TREK-1 and TREK-2 in thallium flux assays respectively. |
| PC-25574 |
VU6080824
Kir2.1 inhibitor
|
VU6080824 is a potent, selective inhibitor of the inward-rectifier potassium channel Kir2.1 with IC50 of 5.9 uM in Kir2.1 thallium flux assays, selective relative to Kir1.1 and Kir4.1 up to 10 uM. |
| PC-25544 |
VU6032735
SLO3 inhibitor
|
VU6032735 is a highly potent, subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 of 165 nM (hSLO3), 172-fold selective over hERG. |
| PC-25468 |
DCY1020
TMEM175 agonist
|
DCY1020 is a potent, specific small molecule agonist of transmembrane protein 175 (TMEM175) with EC50 of 3.7 uM, binds to TMEM175 with SPR KD of 8.3 uM. |
