| Cat. No. |
Product Name |
Information |
| PC-24597 |
ONO-TR-772
TERK inhibitor
|
ONO-TR-772 (VU6018042) is a potent, selective and CNS penetrant TREK (TWIK related K+ channel) inhibitor with IC50 of 15 nM (TREK-1, human manual patch clamp (MPC)), equipotent with TREK-2. |
| PC-24526 |
DHP-103
KCa3.1 inhibitor
|
DHP-103 is a potent, highly selective inhibitor of intermediate-conductance calcium-activated K+ channel KCa3.1 with IC50 of 6.1 nM, exhibits exquisite selectivity over calcium channels and a panel of >100 additional molecular targets. |
| PC-24166 |
Opakalim
Kv7.2/7.3 activator
|
Opakalim (BHV-7000) is a potent, selective small molecule activator of Kv7.2/7.3 potassium channel with EC50 of 0.6 uM, shows minimal GABAA receptor activation, exhibits potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. |
| PC-24079 |
ONO-2920632
TREK-2 activator
|
ONO-2920632 (VU6011887) is a potent, highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2, K2P10.1) activator with EC50 of 0.3 uM (Emax=184%). |
| PC-23869 |
Ebio3
KCNQ2 inhibitor
|
Ebio3 is a potent, subtype-selective inhibitor of potassium channel KCNQ2 (Kv7.2), efficiently suppresses KCNQ2 currents with IC50 of 1.2 nM. |
| PC-23868 |
Ebio2
KCNQ2 activator
|
Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV. |
| PC-23631 |
GiGA1
GIRK1/2 activator
|
GiGA1 is a selective G-protein-independent activator of GIRK channels, targets the alcohol pocket and specifically activates GIRK1/GIRK2 with EC50 of 31 uM. |
| PC-22928 |
2-PPA
TMEM175 inhibitor
|
2-PPA is a selective TMEM175 inhibitor with IC50 of 31 uM, 26-fold selectivity for TMEM175 compared to hKv3.1, increases lysosomal degradative activity. |
| PC-22344 |
CVN293
KCNK13 inhibitor
|
CVN293 (CVN-293) is a potent, selective and brain permeable potassium (K+) ion channel KCNK13 (THIK-1, K2P13.1) inhibitor with IC50 of 41 nM and 28 nM for human and mouse KCNK13, respectively. |
| PC-21738 |
PNU37883A
Kir6 inhibitor
|
PNU37883A (PNU37883 hydrochloride) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker with IC50 of 6 uM and 15 uM for Kir6.1/SUR2B and Kir6.2/SUR2B, respectively. |
| PC-21736 |
Glibenclamide
KATP inhibitor
|
Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor, directly binds and blocks the SUR1 subunits of KATP. |
| PC-21735 |
VU0071063
Kir6.2/SUR1 activator
|
VU0071063 is a potent and specific Kir6.2/SUR1 opener with EC50 of 7.44 uM, inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. |
