| Cat. No. |
Product Name |
Information |
| PC-72462 |
A293
TASK-1 blocker
|
A293 (AVE1231) is a potent and antiarrhythmic compound and selective inhibitor of two-pore-domain potassium channel TASK-1 (KCNK3, hK2P3.1). |
| PC-38131 |
GAT1508
GIRK1/2 activator
|
GAT1508 (GAT-1508) is a potent, specific activator for brain-expressed GIRK1/2 channels (EC50=75 nM), specifically activates the brain GIRK1/2 over the cardiac GIRK1/4. |
| PC-36155 |
IQM-266
Kv4.3 inhibitor
|
IQM-266 (IQM266) is a DREAM (Downstream Regulatory Element Antagonist Modulator) ligand (Kd=4.63 uM), inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. |
| PC-36154 |
VU0810464
GIRK activator
|
VU0810464 (VU 0810464, VU464) is a selective neuronal GIRK channels activator, displays nanomolar potency for GIRK1/2 (EC50=163 nM) and improved brain penetration. |
| PC-36142 |
PF-04895162
Kv7.2/Kv7.3 activator
|
PF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels, also known as KCNQ2/3 and KCNQ3/5 channels. |
| PC-35994 |
TRAM-34
IKCa1 inhibitor
|
TRAM-34 (TRAM34) is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (IKCa1) with Kd of 20 nM. |
| PC-35863 |
VU0466551
GIRK activator
|
VU0466551 (VU-0466551) is a potent, selective, small-molecule GIRK activator with EC50 of 70.6 nM (GIRK1/2 channels). |
| PC-35862 |
VU0529331
GIRK1 activator
|
VU0529331 (VU 0529331) is the first synthetic small molecule activator of non-GIRK1-containing GIRK (non-GIRK1/X) channels with EC50 of 5.1 µM and 5.2 µM for GIRK2 and GIRK1/2 in HEK293 cells, respectively. |
| PC-35564 |
AP14145
KCa2.2/KCa2.3 inhibitor
|
AP14145 (AP-14145) is a potent, selective negative allosteric modulator of KCa2.2 and KCa2.3 with equal potency (IC50=1.1±0.3 uM). |
| PC-35388 |
IK1 inhibitor PA-6
IK1 inhibitor
|
IK1 inhibitor PA-6 is an efficient, specific inhibitor of inward rectifier current (IK1), blocks KIR2.x currents of human and mouse with IC50 of 12-15 nM. |
| PC-35211 |
VU0134992
Kir4.1 inhibitor
|
VU0134992 (VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays. |
| PC-63569 |
BMS-394136
Kv1.5 inhibitor
|
BMS-394136 is a potent, selective IKur/Kv1.5inhibitor, increases atrial action potential duration (APD) and prolongs AERP but not VERP in both rabbits and beagles.. |
