| Cat. No. |
Product Name |
Information |
| PC-21733 |
VU0542270
Kir6.1/SUR2B inhibitor
|
VU0542270 is the first selective inhibitor of vascular Kir6.1/SUR2B KATP channel with IC50 of 129 nM, >300-fold selective over other members of the Kir channel family. |
| PC-21704 |
Guangxitoxin 1E
Kv2 channel inhibitor
|
Guangxitoxin 1E is a potent, specific inhibitor of Kv2.1 (KCNB1) and Kv2.2 with IC50 of 1-3 nM, has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, also inactive against calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8. |
| PC-21613 |
KCNQ2 activator Ebio1
KCNQ2 activator
|
KCNQ2 activator Ebio1 is a potent and subtype-selective activator for the voltage-gated potassium channel KCNQ2 (Kv7.2) with EC50 of 247.3 nM, directly opens the KCNQ2 channel. |
| PC-21564 |
AUT00201
Kv3 modulator
|
AUT00201 is a potent, selective Kv3 potassium channels positive allosteric modulator (PAM), increases the Kv3.1, Kv3.2 and Kv3.4 currents measured at -15mV in a concentration-dependent manner with pEC50 values of 6.15, 6.52, and 5.6, respectively. |
| PC-20745 |
LAKI
TREK channel inhibitor
|
LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels. |
| PC-20702 |
ML308
KCNK9 inhibitor
|
ML308 (ML-308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively. |
| PC-20698 |
PK-THPP
TASK-3 inhibitor
|
TASK-3 inhibitor 23 is a potent, selective inhibitor of TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channel with IC50 of 30 nM, 10-fold selectivity over TASK-1. |
| PC-20299 |
GIRK1/4 inhibitor 14b
GIRK1/4 inhibitor
|
GIRK1/4 inhibitor 14b is a potent, brain-sparing GIRK1/4 inhibitor with IC50 of 0.1 uM, exhibits excellent selectivity over GIRK1/2 channel. |
| PC-20298 |
NIP-142
Kv1.5 inhibitor
|
NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM. |
| PC-49848 |
VU0546110
Sperm SLO3 channel inhibitor
|
VU0546110 (VU 0546110) is a potent, selective inhibitor of the sperm-specific potassium channel SLO3 with IC50 of 1.29 uM, impairs sperm function. |
| PC-49839 |
Retigabine
Kv7 opener
|
Retigabine (D-23129, XEN496) is an anticonvulsant compound and KV7 channel agonist (opener), enhances activation of KCNQ2/Q3 potassium channels. |
| PC-49797 |
ACOU001
Kv7.4 activator
|
ACOU001 (ACOU 001) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with potential effect against ge-related hearing loss (ARHL) and other hearing impairments related to compromised KV7.4 function. |
