| Cat. No. |
Product Name |
Information |
| PC-63511 |
LUF7346
hERG modulator
|
LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation. |
| PC-63348 |
PF-06807656
ROMK inhibitor
|
PF-06807656 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1a) inhibitor with IC50 of 61 nM for hROMK in patch-clamp assays. |
| PC-63222 |
JNJ303
IKs blocker
|
JNJ303 is a potent, specific delayed rectifier potassium current I(Ks) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents). |
| PC-63221 |
L-364373
Kv7.1 activator
|
L-364373 (R-L3) is a stereospecific activator of cardiac slowly activating delayed rectifier K+ current (IKs) and KV7.1 (KCNQ1) channels. |
| PC-43063 |
NS-1619
BKCa activator
|
NS-1619 (NS1619) is a selective large-conductance Ca(2+)-dependent K+ channel (BKCa channel) activator with EC50 of 3.6 uM. |
| PC-42995 |
ML365
KCNK3/TASK1 inhibitor
|
ML365 is a potent and selective inhibitor of KCNK3/TASK1 potassium channel, blocks TASK1 channels in both the thallium influx fluorescent assay (IC50=4 nM) and an automated electrophysiology assay (IC50=16 nM). |
| PC-42992 |
ML277
Kv7.1 activator
|
ML277 (CID53347902) is a potent and selective Kv7.1 (KCNQ1) potassium channel activator with EC50 of 260 nM, displays highly selectivity against other KCNQ channels (>100-fold selectivityover KCNQ2 and KCNQ4). |
| PC-63156 |
E-403
hERG inhibitor
|
E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr). |
| PC-63068 |
Linopirdine dihydrochloride
Kv7 inhibitor
|
Linopirdine (DUP-996) dihydrochloride is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker. |
| PC-63067 |
Linopirdine
Kv7 inhibitor
|
Linopirdine (DUP-996, Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blocker. |
| PC-63066 |
XE991
Kv7 inhibitor
|
XE991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively. |
| PC-62919 |
CP-339818
Kv1.3 inhibitor
|
CP-339818 is a potent, selective, non-peptide KV1.3 channel antagonist with IC50 of 200 nM. |
