| Cat. No. |
Product Name |
Information |
| PC-60653 |
NS19504
BKCa activator
|
A novel selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM. |
| PC-60648 |
AUT2
Kv3 modulator
|
AUT2 is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 0.9 and 1.9 uM for Kv3.1b and Kv3.2a, respectively. |
| PC-60647 |
AUT1
Kv3 modulator
|
AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively. |
| PC-60576 |
ML418
Kir7.1 inhibitor
|
ML418 (ML-418) is the first potent, selective, CNS penetrating inward rectifier potassium channel Kir7.1 (KCNJ13) inhibitor with IC50 of 0.31 uM. |
| PC-60575 |
BNBI
ROMK inhibitor
|
BNBI is a selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM. |
| PC-60573 |
VU714
Kir7.1 inhibitor
|
VU714 is a potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays. |
| PC-60572 |
MRT2000769
Kir7.1 inhibitor
|
MRT2000769 is a potent Kir7.1 inhibitor with IC50 of 2.0 uM, induces long-lasting uterine contractility similar to those observed with VU590. |
| PC-60571 |
VU591
ROMK inhibitor
|
VU591 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 0.24 uM in T1+ flux assays. |
| PC-60570 |
VU590 dihydrochloride
ROMK inhibitor
|
VU590 is the first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK. |
| PC-60569 |
VU590
ROMK inhibitor
|
VU590 is the first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK. |
| PC-60559 |
RX 871024
|
RX 871024 is an imidazoline compound that stimulate insulin release by inhibition of ATP-dependent K+ channels and inducing of Ca2+ mobilization in mouse pancreatic beta-cells. |
| PC-70220 |
Paxilline
BKCa inhibitor
|
Paxilline is a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels that binds to the α-subunit of BKCa with Ki of 1.9 nM. |
