| Cat. No. |
Product Name |
Information |
| PC-27790 |
Zinc Pyrithione
KCNQ potassium channel activator
|
Zinc pyrithione (Zn-Pyrithione, ZnPy) is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump, potentiates potassium currents induced by KCNQ homomultimers, show agonistic activity for KCNQ channels, potently activates both heterologous and native M channels by inducing channel opening at the resting potential, also is a copper ionophore. |
| PC-27787 |
Kv7 blocker compound 106
Kv7 blocker
|
Kv7 blocker compound 106 (C106) is a potent, subtype-selective Kv7 blocker with IC50 of 33.1 nM for Kv7.2/3 channels, without affecting cardiac Kv7.1 channels. |
| PC-27786 |
Kv7 activator compound 60
Kv7 activator
|
Kv7 activator compound 60 is a potent and photochemically stable neuronal Kv7 channel activator with EC50 of 0.1 uM for Kv7.2/Kv7.3 channels. |
| PC-27765 |
Mutant KCNJ5 agonist C105
KCNJ5 agonist
|
Mutant KCNJ5 agonist C105 is a selective, first-in-class mutant KCNJ5 (GIRK4) agonist, increases mutant KCNJ5-induced cell death in adrenal cells, without affecting cells expressing wild-type KCNJ5. |
| PC-27689 |
AUT5
Kv3.1/3.2 modulator
|
AUT5 is a highly selective positive allosteric modulator of Kv3.1 and Kv3.2 channels, induces positive cooperativity and preferential stabilization of the open state with EC50 of 3.2 uM (Kv3.2). |
| PC-27590 |
JG-C3-98
TASK-1/TASK-3 activator
|
JG-C3-98 is a selective and effective activator of K2P channels TASK-1 and TASK-3 with EC50 of 13 uM and 34 uM for hTASK-1 and hTASK-3, respectively. |
| PC-27392 |
UA49
KAT1 inhibitor
|
UA49 is a small molecule inhibitor of plant inward-rectifying potassium channel KAT1, KAT2, promotes a decrease in the cytosolic K+ content in guard cells, conferring significant drought tolerance in Arabidopsis. |
| PC-27285 |
Tenidap
Kir2.3 agonist, 5-LOX/COX inhibitor
|
Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and cyclooxygenase (COX) with anti-inflammatory and immunomodulatory properties.
Tenidap (CP-66248) reduces A 23187-stimulated LTB4 (IC50=18 uM) and PGE2 (IC50=32 nM) synthesis. |
| PC-26570 |
CHET3
TASK-3 agonist
|
CHET3 is a highly selective allosteric activator for TASK-3-containing K2P channels, including TASK-3 homomers and TASK-3/TASK-1 heteromers, displayspotent analgesic effects. |
| PC-26491 |
KCa3.1-IN-1
KCa3.1 inhibitor
|
KCa3.1-IN-1 is a selective small-molecule extracellular inhibitor of KCa3.1 channel (KCNN4) with IC50 of 43.1 uM in duplicate whole-cell patch clamp recordings. |
| PC-26490 |
GLA-1-1
BK channel agonist
|
GLA-1-1 is a small-molecule agonist of large-conductance Ca²⁺-activated K⁺ (BK) channels with EC50 of 3.4 uM, induces autophagy flux by promoting autophagosome-lysosome fusion. |
| PC-26438 |
IQM-22110
KV4.3/KChIP modulator
|
IQM-22110 is a selective small molecule modulator of KV4.3/KChIP channels with IC50 of 28 nM and binding affinity (Kd) of 230 nM to KChIP3, selective for KV4.3/KChIP3 over KV4.3/KChIP2 and KV4.3 channels. |
