| Cat. No. |
Product Name |
Information |
| PC-62064 |
VU0240551
KCC2 inhibitor
|
VU0240551 is a potent, selecticve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 568 nM in K+ uptake assay in KCC2-overexpressing cells. |
| PC-61462 |
NS5806
Kv4.3 activator
|
NS5806 (NS-5806) is a potent Kv4.3 channel activator that mediates the transient outward K+ current (Ito). |
| PC-70331 |
ML297
GIRK1/2 activator
|
ML297 (VU 0456810) is a potent, selective, CNS-penetrant small molecule agonist of GIRK1/2 channel with EC50 of 160 nM. |
| PC-70312 |
RU-TRAAK-2
TRAAK inhibitor
|
RU-TRAAK-2 is a completely reversible K2P channel TRAAK (KCNK4, K2P4.1) inhibitor with IC50 of 0.719 uM for TRAAK-mediated efflux, shows no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2). |
| PC-70311 |
RU-TRAAK-1
TRAAK inhibitor
|
RU-TRAAK-1 is a poorly reversible K2P channel TRAAK (KCNK4, K2P4.1) inhibitor with IC50 of 0.385 uM for TRAAK-mediated efflux, shows no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2). |
| PC-70310 |
RU-GIRK-1
GIRK2 inhibitor
|
RU-GIRK-1 is a potent GIRK2 inhibitor that inhibits GIRK2-mediated flux with an IC50 of 0.35 uM. |
| PC-60984 |
ASP2905
KCNH3 inhibitor
|
ASP 2905 (ASP2905) is a novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM. |
| PC-60945 |
TKN2
TREK channel inhibitor
|
TKN2 is a small molecule allosteric inhibitor of TREK channels with IC50 of 3.8, 1.7 and 10.3 uM for TREK-1, TREK-2 and TRAAK, respectively. |
| PC-60944 |
TKN1
TREK channel inhibitor
|
TKN1 is a small molecule allosteric inhibitor of TREK channels with IC50 of 6.5, 4.4 and 15.7 uM for TREK-1, TREK-2 and TRAAK, respectively. |
| PC-60943 |
28NH
TREK channel inhibitor
|
28NH is a small molecule allosteric inhibitor of TREK channels with IC50 of 5.0, 5.0 and 11.8 uM for TREK-1, TREK-2 and TRAAK, respectively. |
| PC-60942 |
TKDC
TREK channel inhibitor
|
TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively. |
| PC-60843 |
SB335573
hERG agonist
|
SB335573 is a potent, selective hERG potassium channel (Kv11.1) activator. |
