| Cat. No. |
Product Name |
Information |
| PC-60831 |
ITP-2
hERG activator
|
ITP-2 is a novel small molecule activator of Kv11.1 (hERG) channel (216% over control at 3 uM for hERG1a activation). |
| PC-60824 |
ICA-27243
Kv7.2/Kv7.3 activator
|
ICA-27243 (ICA-207243) is a potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM. |
| PC-60823 |
ICA-069673
Kv7.2/Kv7.3 activator
|
ICA-069673 (ICA069673) is a novel potent, selective and orally active KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.69 uM, 20-fold selectivity over KCNQ3/Q5. |
| PC-60782 |
NS13001
KCa2.2/KCa2.3 inhibitor
|
NS13001 is a potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively. |
| PC-60781 |
SKA-111
KCa3.1 activator
|
SKA-111 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM. |
| PC-60780 |
SKA-121
KCa3.1 activator
|
SKA-121 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 109 nM. |
| PC-60688 |
BMS-204352
Potassium channel opener
|
Flindokalner (BMS-204352) is a potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches. |
| PC-60687 |
DMP543
Kv7 inhibitor
|
DMP543 (XR-543) is a potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7 uM. |
| PC-60686 |
XE 991 dihydrochloride
Kv7 inhibitor
|
XE 991 dihydrochloride is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively. |
| PC-60669 |
RY796
Kv2 inhibitor
|
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively. |
| PC-60655 |
Charybdotoxin
BKCa inhibitor
|
Charybdotoxin (ChTX) selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK). |
| PC-60654 |
Iberiotoxin
BKCa inhibitor
|
Iberiotoxin (IbTX) is a selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM. |
