Cat. No. |
Product Name |
Information |
PC-20934 |
WB737
STAT3 inhibitor
|
WB737 is a potent and selective STAT3 inhibitor, directly binds to the STAT3 Src homology 2 (SH2) domain with KD value of 1.34 nM. |
PC-20634 |
IST5-002
Stat5a/b inhibitor
|
IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells. |
PC-20120 |
K1836
STAT3 inhibitor
|
K1836 is a small molecule Stattic analog inhibitor of STAT3 signalling. |
PC-49462 |
WB436B
STAT3 inhibitor
|
WB436B is a potent and highly selective small molecule inhibitor of STAT3, specifically targets the STAT3-SH2 domain with KD value of 94.3 nM. |
PC-49434 |
DR-1-55
STAT3 inhibitor
|
DR-1-55 (DR-155) is a selective STAT3 inhibitor that covalently modifies a cysteine in the SH2 domain of STAT3. |
PC-49088 |
STX-0119
STAT3 inhibitor
|
STX-0119 is a specific small molecule STAT3 dimerization inhibitor, binds to STAT3-SH2 domain and inhibits STAT3 transcription in STAT3-dependent luciferase reporter gene assay in HeLa cells with IC50 of 74 uM. |
PC-47064 |
ODZ10117
STAT3 inhibitor
|
ODZ10117 is a small molecule inhibitor of STAT3, effectively inhibits the level of tyrosine phosphorylated STAT3 in various cancer cell lines. |
PC-38849 |
W1131
STAT3 inhibitor
|
W1131 is a potent and selective STAT3 inhibitor with Kd of 7.55 uM in surface plasmon resonance (SPR) assays, inhibits STAT3 Tyr705 phosphorylation, triggers ferroptosis and possesses potent anti-tumor effects both in vitro and in vivo. |
PC-73189 |
WP1066
STAT3 inhibitor
|
WP1066 is a potent, cell-active STAT3 pathway inhibitor, inhibits human malignant glioma U87-MG and U373-MG cells in vitro with IC50 of 5.6 and 3.7 uM. |
PC-72849 |
SS-4
STAT3 inhibitor
|
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. |
PC-38322 |
Stafia-1 prodrug
STAT5a inhibitor
|
Stafia-1 prodrug is the cell-permeable prodrug of Stafia-1 (Cat. PC-38321), and is suitable for cell based assays, inhibits tyrosine phosphorylation of STAT5a with selectivity over STAT5b in cultured human leukemia cells. |
PC-38321 |
Stafia-1
STAT5a inhibitor
|
Stafia-1 is a selective inhibitor of STAT5a with Ki of 10.9 uM, preferentially inhibits STAT5a over the close homologue STAT5b (>9-fold) and other STAT family member. |