| Cat. No. |
Product Name |
Information |
| PC-26212 |
Pomstafib-2-CR
STAT5b inhibitor
|
Pomstafib-2-CR is the ester prodrug of Stafib-2-CR, which is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM. |
| PC-26211 |
Stafib-2-CR
STAT5b inhibitor
|
Stafib-2-CR is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM, shows 69-fold selectivity over STAT5a. |
| PC-24861 |
STAT6-IN-5
STAT6 inhibitor
|
STAT6-IN-5 (compound 84) is a potent, selective STAT6 inhibitor with IC50 of 0.24 uM, compound 84 extracted from patent WO2024071439 A1. |
| PC-24860 |
STAT6 ligand-2
STAT6 ligand
|
STAT6 ligand-2 is a potent, specific ligand of STAT6 used for synthesizing STAT6 PROTAC degraders. |
| PC-24794 |
STAT6-IN-4
STAT6 inhibitor
|
STAT6-IN-4 (Example 78) is a potent, selective STAT6 inhibitor with IC50 of 0.34 uM, example 78 in patent WO2024071439 A1. |
| PC-24628 |
BMA097
STAT3 inhibitor
|
BMA097 is a small molecule STAT3 inhibitor with IC50 of 1.8 uM in STAT3-dependent luciferase assays, binds directly to the SH2 domain of STAT3 and specifically inhibits STAT3 Tyr705 phosphorylation and activation. |
| PC-24625 |
LLY17
STAT3 inhibitor
|
LLY17 (Compound 9) is an orally available, potent, and selective STAT3 inhibitor, directly and selectively inhibits the pY705 site of STAT3 with Ki of 400 nM. |
| PC-24624 |
SMY002
STAT3 inhibitor
|
SMY002 is a potent novel small molecule STAT3 inhibitor, directly interacts and binds to STAT3 with SPR IC50 of 2 uM, inhibits the transcriptional activity of STAT3. |
| PC-24235 |
Pomstafori-1
STAT4 inhibitor
|
Pomstafori-1 is the cell-permeable prodrug of Stafori-1, inhibits STAT4 Tyr693 phosphorylation in NK-92 cell with IC50 of 3.3 uM, selectively inhibits STAT4 activation and IFN-γ induction in cultured human cells. |
| PC-23511 |
HJC0416 hydrochloride
STAT3 inhibitor
|
HJC0416 hydrochloride is an orally bioavailable small-molecule STAT3 inhibitor, decreases the STAT3 promoter activity in MDA-MB-231 cells with IC50 of 5 uM. |
| PC-22565 |
Fludarabine
STAT1 inhibitor, NAT10 inhibitor
|
Fludarabine (NSC118218) is a fluorinated purine analogue ands DNA synthesis inhibitor with antineoplastic activities, inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes. |
| PC-22095 |
YY002
STAT3 inhibitor
|
YY002 is a potent, selective STAT3 inhibitor, selectively binds to the STAT3 Src Homology 2 (SH2) domain (KD=2.24 nM) over other STAT members, inhibits STAT3 Tyr705 and Ser727 phosphorylation. |
