| Cat. No. |
Product Name |
Information |
| PC-27724 |
S-570
STING antagonist
|
S-570 is a potent, covalent, orally available STING antagonist with IC50 of 41 nM (hSTING), covalently binds to Cys91, inhibits IFN-β secretion in 2′,3′-cGAMP-stimulated THP-1 cells with IC50 of 18 nM. |
| PC-27714 |
DDO-7432
STING inhibitor
|
DDO-7432 is a specific, orally bioavailable molecular glue that induces aberrant STING oligomerization, inhibits STING activity with IC50 of 1.37 uM in IRF luciferase reporter assays in THP-1-Dual cells, induces self-association of STING to inhibit STING-dependent signal transduction. |
| PC-27713 |
DDO-6513
STING inhibitor
|
DDO-6513 is a specific molecular glue that induces aberrant STING oligomerization, inhibits STING activity with IC50 of 1.93 uM in IRF luciferase reporter assays in THP-1-Dual cells and ITC Kd of 151 nM, binds to the wing region of butterfly-shaped LBDs of STING, specifically inhibits human STING activation. |
| PC-27124 |
STING agonist C92
STING agonist
|
STING agonist C92 is a potent, allosteric hSTING agonist with EC50 of 36.2 nM for enhancement of the association of [3H]cGAMP (1 nM) to STING. |
| PC-27088 |
INI3069
STING agonist
|
INI3069 is a human-selective STING agonist, inhibits trafficking of STING to the Golgi and blocks STING-mediated TFEB dephosphorylation and autophagy, enhances both humoral responses to co-administered antigen and anti-tumor responses. |
| PC-24633 |
STING inhibitor SI-43
STING inhibitor
|
STING inhibitor SI-43 is a potent small molecule inhibitor of stimulator of interferon genes (STING) with IC50 of 0.11 uM against cGAMP-induced STING activation in THP1-Blue ISG cells. |
| PC-24614 |
TAK-676
STING agonist
|
TAK-676 (Dazostinag disodium) is a potent, selective stimulator of interferon genes (STING) agonist with highly selective binding and activation of STING proteins from various species, with Kd values of 0.01 uM, 0.008 uM, 0.011 uM, and 0.027 uM for mouse, rat, cynomolgus monkey, and human STING orthologs, respectively. |
| PC-23967 |
Astin C
STING inhibitor
|
Astin C is a specific, cyclopeptide inhibitor of cGAS-STING signaling, binds to STING C-terminal binding domain (CBD) with Kd of 2.37 uM (STING-CTD-H232), blocks the recruitment of IRF3 onto the STING signalosome and restricts STING activation and signaling. |
| PC-22806 |
SNX281
STING agonist
|
SNX281 is a systemically active STING agonist that binds to the STING protein, promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. |
| PC-38078 |
SN-011
STING inhibitor
|
SN-011 (SN011) is a potent, selective STING antagonist with IC50 of 76 nM (STING signaling inhibition). |
| PC-22439 |
STING degrader AK59
STING degrader
|
STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation. |
| PC-22431 |
BDW568
STING agonist
|
BDW568 is a non-nucleotide agonist of human STING (stimulator of interferon genes) and type-I interferon signaling activator. |
