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Cat. No. Product Name CAS No. Information
PC-61814

SB 737050A

583045-76-5 SB 737050A is a potent, selective 5-HT6 receptor antagonist to prevent relapse intio addiction.
PC-61812

GSK-812

630407-66-8 GSK-812 is a potent neuroprotectant that can induce GDNF in normal and diseased retina, shows has polypharmacology antagonizing multiple receptors, including D2 and D3 receptors, and 5-HT2A, 2C, and 5-HT6 receptors.
PC-61729

Revexepride

219984-49-3 Revexepride (SSP 002358;SPD-557) potent, highly selective 5-HT4 receptor agonist for the treatment of gastroesophageal reflux disease.

Other Indication

Phase 2 Discontinued

PC-61583

GSK-588045

876922-98-4 GSK-588045 is a potent and selective 5-HT1A/B/D receptor antagonist with Ki of 9.5/8.8/9.8, respectively; exhibits high selectivity over human hERG potassium channels, favorable pharmacokinetics, and excellent activity in vivo in rodent pharmacodynamic (PD) models; demonstrates potential as a faster acting antidepressant/anxiolytic with reduced side-effect burden.

Anxiety

Phase 1 Clinical

PC-61504

AVN-101

1025725-91-0 A higly potent, orally bioavailable, BBB permeable 5-HT7 receptor antagonist with Ki of 153 pM, with slightly lesser potency toward 5-HT6, 5-HT2A and 5HT-2C (Ki = 1.2-2.0  nM); also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors; demonstrates reasonable anxiolytic and anti-depressive activities in animal models of CNS diseases with low safety concerns.

Anxiety

Phase 2 Clinical

PC-61503

AVN-322 free base

1194574-33-8 A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia; significantly restores both scopolamine- and MK-801-induced cognitive dysfunction and demonstrates antipsychotic potential.

Alzheimer Disease

Phase 2 Clinical

PC-61502

AVN-322

1194574-68-9 A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia; significantly restores both scopolamine- and MK-801-induced cognitive dysfunction and demonstrates antipsychotic potential.

Alzheimer Disease

Phase 2 Clinical

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