| Cat. No. |
Product Name |
Information |
| PC-35969 |
PF-06873600
CDK2/4/6 inhibitor
|
PF-06873600 (Ebvaciclib, PF06873600) is a potent, orally bioavailable inhibitor of cyclin-dependent kinase (CDK) with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. |
| PC-35809 |
CDK9 inhibitor HH1
CDK9 inhibitor
|
CDK9 inhibitor HH1 is a novel potent, highly selective CDK9 inhibitor. |
| PC-35808 |
MC180295
CDK9 inhibitor
|
MC180295 (MC-180295, MC 180295) is a novel potent, highly selective CDK9 inhibitor with IC50 of 5 nM, displays >22-fold selectivity over other CDKs. |
| PC-35787 |
LY3143921
Cdc7 inhibitor
|
LY3143921 (LY-3143921) is an orally available, potent, selective inhibitor of Cdc7 kinase inhibitor, inhibits CDC7/DBF4 I and pMCM2 (S53) with IC50 values of 3.3 nM and 290 nM, respectively.. |
| PC-35688 |
JSH-150
CDK9 inhibitor
|
JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM). |
| PC-35631 |
iCDK9
CDK9 inhibitor
|
iCDK9 (i-CDK9) is a potent, highly selective CDK9 inhibitor (IC50<0.4 nM, CDK9-CycT1 kinase), exhibits >600-fold selectivity toward CDK1-CycB, CDK2-CycA, CDK4-CycD1, CDK7-CycH-MAT1 and CDK8-CycC. |
| PC-35630 |
Amt-87
|
Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186. |
| PC-35532 |
Compound 919278
CDK12 inhibitor
|
Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK. |
| PC-35525 |
CDK12 inhibitor 2
CDK12 inhibitor
|
CDK12 inhibitor 2 is (CDK12-IN-2) is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9. |
| PC-35361 |
BAY-320
BUB1 inhibitor
|
BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM. |
| PC-35250 |
AZD4573
CDK9 inhibitor
|
AZD4573 (AZD-4573) is a potent and selective inhibitor of CDK9 with IC50 of <4 nM, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases. |
| PC-35248 |
Cdc7 inhibitor X
Cdc7 inhibitor
|
Cdc7 inhibitor X is a potent inhibitor of Cdc7 kinase with pIC50 of 10.01 against CDC7/DBF4 in TR-FRET assays. |
