| Cat. No. |
Product Name |
Information |
| PC-42418 |
IMD-0354
IKKβ inhibitor, AQP4 inhibitor
|
IMD-0354 (AER-270) is a potent IκB kinase β (IKKbeta) inhibitor, also is a potent inhibitor of glutamine uptake. |
| PC-42243 |
TPCA-1
IKK-2 inhibitor
|
TPCA-1 (IKK-2 Inhibitor IV) is a potent, selective and orally bioavailable IKK-2 inhibitor with IC50 of 63 nM, TNF cell IC50 of 0.4 uM. |
| PC-42631 |
BMS-345541
IKK2 inhibitor
|
BMS-345541 is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM. |
| PC-45622 |
AZD3264
IKK2 inhibitor
|
AZD3264 is a selective small molecule inhibitor of IkB-kinase IKK2 for treatment of inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
| PC-21476 |
Shikonin
NEMO/IKKβ inhibitor
|
Shikonin is a specific inhibitor of the IKKβ/NEMO complex PPI with IC50 of 170 nM, blocks the complex formation in vitro, in cell culture and in animal models. |
| PC-21368 |
MHPAP
IKK inhibitor
|
MHPAP is a potent cell-permeable anti-cytokine compound, inhibits inflammatory cytokines in monocyte/macrophage-like cells, directly binds to IκB kinase (IKK). |
| PC-20897 |
Wedelolactone
IKK inhibitor
|
Wedelolactone is a small molecule inhibitor of LPS-induced caspase-11 expression by directly inhibits the IKK Complex, also inhibits 5-lipoxygenase with IC50 of 2.5 uM. |
| PC-20619 |
Amlexanox
IKKε/TBK1 inhibitor
|
Amoxanox (AA-673) is a high affinity, specific inhibitor of IKKε and TBK1 with IC50 of 1-2 uM for both, without effect on IKKα or IKKβ. |
| PC-38528 |
AZ13102909
TBK1 inhibitor
|
AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases. |
| PC-73128 |
BAY-985
TBK1/IKKε inhibitor
|
BAY-985 (BAY985) is a potent and highly selective TBK1/IKKε inhibitor with IC50 of 2 nM (low ATP assay). |
| PC-35736 |
PIAA
|
PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells. |
| PC-43364 |
ACHP hydrochloride
|
ACHP hydrochloride is a potent and specific inhibitor for IKK-β with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM, exhibits good selectivity over other kinases, such as IKK3, Syk and MKK4 (IC50>20 uM). |
