| Cat. No. |
Product Name |
Information |
| PC-21209 |
TY-52156
S1P3 inhibitor
|
TY-52156 is a potent, selective S1P3 receptor antagonist with Ki of 110 nM. |
| PC-20462 |
LPA2 antagonist 58
LPA2 inhibitor
|
LPA2 antagonist 58 is a highly potent and selective LPA2 receptor antagonist with pIC50 of 8.22 (hLPA2) and 8.19 (mLPA2), >1000-fold selectivity over LPA1 receptor. |
| PC-20419 |
SLB1122168 hydrochloride
Spns2 inhibitor
|
SLB1122168 hydrochloride is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM. |
| PC-20418 |
SLB1122168
Spns2 inhibitor
|
SLB1122168 is a potent, specific inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits Spns2-mediated S1P release with IC50 of 94 nM. |
| PC-49650 |
AM095
LPA1 antagonist
|
AM095 (AM-095) is a potent, selective and orally active lysophosphatidic acid type 1 receptor (LPA1) antagonist with IC50 of 0.98 and 0.73 uM for hLPA1 and mLPA1 in GTP S binding assays, respectively, with no LPA1 agonism. |
| PC-49229 |
H2L5186303
LPA2 antagonist
|
H2L5186303 is a potent, selective LPA2 receptor antagonist with IC50 of 8.9 nM, no significant activity against LPA1 and LPA3 receptors (IC50>1,000 nM), inhibits LPA(2) mediated Erk activation and proliferation of HCT-116 cells. |
| PC-49228 |
UCM-14216
LPA2 antagonist
|
UCM-14216 (UCM14216) is a potent and selective antagonist of type 2 lysophosphatidic acid receptor (LPA2) with KD value of 1.3 nM and IC50 of 1.9 uM. |
| PC-49026 |
ASP1126
S1P1 agonist
|
ASP1126 is a potent, selective and orally active sphingosine-1-phosphate (S1P) agonist with EC50 of 7.12 and 517 nM for hS1P1 and hS1P3 in GTPgS-binding assays, respectively. |
| PC-38763 |
SLF1081851
Spns2 inhibitor
|
SLF1081851 is a potent, in vivo-active inhibitor of S1P transporter spinster homologue 2 (Spns2), inhibits S1P release with IC50 of 1.93 uM in HeLa cells. |
| PC-72841 |
ALESIA
S1PR3 agonist
|
ALESIA is a sphingosine-1-phosphate receptor 3 (S1PR3)-G12-biased agonist and selectively induces G12 signal. |
| PC-72349 |
BMS-986278
LPA1 antagonist
|
BMS-986278 (BMS986278) is a potent, selective lysophosphatidic acid receptor 1 (LPA1) antagonist with human LPA1 Kb of 6.9 nM. |
| PC-35275 |
SAR-100842
|
Fipaxalparant (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays. |
