| Cat. No. |
Product Name |
Information |
| PC-60663 |
NSC45586
PHLPP inhibitor
|
NSC45586 is a selective protein phosphatase PHLPP inhibitor with IC50 of 4 uM for PP2C domain of PHLPP2. |
| PC-50005 |
AQX 1125 acetate
SHIP1 activator
|
AQX 1125 acetate (Rosiptor) is a sepecific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM. |
| PC-50004 |
AQX 1125
SHIP1 activator
|
AQX 1125 (Rosiptor) is a specific, orally bioavailable SHIP1 activator with no effect on functional androgen, oestrogen, oestrogen-related receptor α, glucocorticoid, mineralocorticoid and progesterone receptor at 30 uM. |
| PC-70159 |
NCI-83633
PP2C inhibitor
|
NCI-83633 (Leucine-2-napthylamide) is a small molecule inhibitor of PP2C that activates extensive 3' cleavage at a concentration 50-fold below that required by fluoride or CP. |
| PC-70158 |
DT-061
PP2A activator
|
SMAP (DT-061, NZ-8-061) is an orally bioavailable small molecule activator of PP2A, inhibits KRAS-driven tumor growth. |
| PC-70157 |
CS-11
PP2A-β-catenin inhibitor
|
CS-11 is a novel small molecule inhibitor that inhibits PP2A and β-catenin interaction by selectively engaging PR55α binding site (Kd=45 pM). |
| PC-70156 |
MP07-66
PP2A activator
|
MP07-66 is a novel FTY720 analog that acts as PP2A activator, disrupts the SET/PP2A interaction devoid of immunosuppressive effects leads to the reactivation of PP2A. |
| PC-70155 |
LB-102
PP2A inhibitor
|
LB-102 (LB-1.2, LB 102) is a potent, selective serine/threonine protein phosphatase 2A (PP2A) inhibitor with IC50 of 0.4 uM. |
| PC-70136 |
AS1949490
SHIP2 inhibitor
|
AS-1949490 (AS1949490) is a potent, selective SHIP2 inhibitor with IC50 of 0.34/0.62 uM for mouse/human SHIP2. |
| PC-60249 |
BN82002
Cdc25 inhibitor
|
BN82002 is a potent Cdc25 dual specificity phosphatase inhibitor with IC50 of 2-6 uM for Cdc25A/B/C. |
| PC-60248 |
NSC95397
Cdc25 inhibitor
|
NSC95397 is a potent, selective, reversible Cdc25 dual specificity phosphatase inhibitor with Ki of 32/96/40 nM for Cdc25A/B/C, respectively. |
| PC-60183 |
DUSP6 inhibitor BCI
DUSP6 inhibitor
|
BCI (NSC150117) is a small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM. |
