| Cat. No. |
Product Name |
Information |
| PC-38070 |
IACS-13909
SHP2 inhibitor
|
IACS-13909 (IACS13909) is a potent, and selective allosteric inhibitor of SHP2 with IC50 of 15.7 nM (hSHP2 full length), Kd of 32 nM (ITC). |
| PC-36051 |
SHP2 inhibitor 14
|
SHP2 inhibitor 14 is a novel potent, selective, allosteric, orally acitve SHP2 inhibitor with IC50 of 28 nM. |
| PC-36050 |
SHP389
SHP2 inhibitor
|
SHP389 (SHP-389, SHP 389) is a novel potent, selective, allosteric SHP2 inhibitor with IC50 of 36 nM, shows with impressive hERG selectivity (IC50>30 uM). |
| PC-36040 |
SHP2 inhibitor 9
SHP2 inhibitor
|
SHP2 inhibitor 9 is a potent, selective inhibitor of SHP2 with IC50 of 48 nM, inhibits p-ERK in KYSE520 cells with IC50 of 28 nM. |
| PC-36039 |
SHP2 inhibitor 8
SHP2 inhibitor
|
SHP2 inhibitor 8 is a potent, selective inhibitor of SHP2 with IC50 of 5 nM, inhibits p-ERK in KYSE520 cells with IC50 of 5 nM. |
| PC-36038 |
SHP394
SHP2 inhibitor
|
SHP394 (SHP-394, SHP 394) is a potent, selective, orally bioavailable inhibitor of SHP2 with IC50 of 23 nM, shows p-ERK inhibition with IC50 of 18 nM in cellular assays. |
| PC-35819 |
SHP2 inhibitor LY6
SHP2 inhibitor
|
SHP2 inhibitor LY6 (LY6) is a small molecule inhibitor that stabilizes the autoinhibited conformation of the oncogenic tyrosine phosphatase SHP2, inhibits SHP2 with IC50 of 9.8 uM, 7-fold selectivity over SHP1. |
| PC-35733 |
7-BIA
PTPRD inhibitor
|
7-BIA is a small molecule 7-butoxy illudalic acid analog that targets receptor-type protein tyrosine phosphatase D (PTPRD, IC50=1-3 uM) with some specificity. |
| PC-35687 |
PP1 inhibitor C31
PP1 inhibitor
|
PP1 inhibitor C31 is a 1E7-03 analog and protein phosphatase 1 (PP1) targeting small molecule with Kd of 1.88 uM, inhibits Ebola virus (EBOV) transcription and replication. |
| PC-35665 |
BI-0314
STEP activator
|
BI-0314 (BI0314) is an allosteric activator of protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) with potency of 56% at 500 uM, displays no activity against hPTP1B and hTCPTP.. |
| PC-35654 |
AAL(S)
PP2A activator
|
AAL(S) is the chiral deoxy analog of the FDA approved drug FTY720, has been shown to inhibit proliferation and apoptosis in several cancer cell lines by activating protein phosphatase 2A (PP2A). |
| PC-35653 |
SH-BC-893
PP2A activator
|
SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve. |
