| Cat. No. |
Product Name |
Information |
| PC-72973 |
DIPQUO
Alkaline phosphatase activator
|
DIPQUO is a small molecule activator of the bone marker alkaline phosphatase (ALP) expression with EC50 of 6.27 uM, p38-β mediate DIQPUO-driven osteoblast differentiation effect. |
| PC-72803 |
MPK5 inhibitor 1
MKP5 inhibitor
|
MPK5 inhibitor 1 (MPK5-IN-1, MPK5 inhibitor compound 1) is a potent, selective allosteric inhibitor of MAPK phosphatase MKP5 with Kd/IC50 of 1.0/3.9 uM. |
| PC-72611 |
PF-07284892
SHP2 inhibitor
|
PF-07284892 (PF 07284892) is a small molecule inhibitor of SHP2 that may block MAPK signaling and lead to tumor growth inhibition. |
| PC-72527 |
SMIP-30
PPM1A inhibitor
|
SMIP-30 is a potent and selective inhibitor of PPM1A with IC50 of 1 uM, selectively inhibits the phosphatase activity of PPM1A. |
| PC-72326 |
TK-453
SHP2 inhibitor
|
TK-453 (TK453) is a potent, selective SHP2 allosteric inhibitor with IC50 of 18.76 and 179 nM for SHP2-WT and SHP2-E76K, respectively. |
| PC-72034 |
PTPN22 inhibitor L-1
PTPN22 inhibitor
|
PTPN22 inhibitor L-1 is a selective, competitive small molecule inhibitor of PTPN22 with IC50 of 1.4 uM, Ki of 0.5 uM, 7- to 10-fold selectivity for PTPN22 over 16 similar PTPs. |
| PC-72033 |
CNBDA
SHP2 inhibitor
|
CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1. |
| PC-38186 |
IACS-15414
SHP2 inhibitor
|
IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM. |
| PC-38184 |
SBI-4668
SHP2 inhibitor
|
SBI-4668 (SBI 4668) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.73/1.8 uM for Wt SHP2/SHP2-E76K, 13-fold selective over PTP1B and 73-fold selective over STEP. |
| PC-38183 |
SBI-2130
SHP2 inhibitor
|
SBI-2130 (SBI 2130) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.22/5.0 uM for Wt SHP2/SHP2-E76K. |
| PC-38181 |
RMC-4630
SHP2 inhibitor
|
RMC-4630 (Vociprotafib) is a potent and selective inhibitor of SHP2, a central node in the RAS signaling pathway. |
| PC-38180 |
TNO155
SHP2 inhibitor
|
Batoprotafib (TNO155) is a highly potent, selective, orally active, and allosteric SHP2 (PTPN11) inhibitor with IC50 of 11 nM. |
