| Cat. No. |
Product Name |
Information |
| PC-21645 |
Voclosporin
Calcineurin inhibitor
|
Voclosporin (ISATX247, ISA247) is a small molecule calcineurin (Protein phosphatase-2B, PP2B) inhibitor, more potency than cyclosporine in vitro, substantially inhibits lymphocyte proliferation, T-cell activation and cytokine production. |
| PC-21457 |
K161
SHIP1/2 inhibitor
|
K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively. |
| PC-21366 |
ATUX-1215
PP2A activator
|
ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo. |
| PC-21296 |
PP5 inhibitor P053
PP5 inhibitor
|
PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity. |
| PC-21074 |
PTPN22 inhibitor NC1
PTPN22 inhibitor
|
PTPN22 inhibitor NC1 is a specific, noncompetitive, allosteric PTPN22 (lymphoid-specific tyrosine phosphatase, LYP) inhibitor with Ki of 4.3 uM, effectively and specifically inhibits LYP-mediated TCR signaling in T cells. |
| PC-20969 |
Compound 182
PTP1B/PTPN2 inhibitor
|
Compound 182 is a highly potent and selective active site competitive inhibitor of PTP1B and PTPN2, inhibits the catalytic activities of PTP1B and PTPN2 with IC50 of 0.63 and 0.58 nM, respectively. |
| PC-20711 |
SBI-221
SHP2-E76K inhibitor
|
SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively. |
| PC-20470 |
PTP1B inhibitor BDB
PTP1B inhibitor
|
PTP1B inhibitor BDB is a natural compound found in marine red algaea, is a selective, cell‐permeable and competitive inhibitor of PTP1B with IC50 of 1.86 uM. |
| PC-20469 |
PTP1B inhibitor BBR
PTP1B inhibitor
|
PTP1B inhibitor BBR is a selective, non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B with IC50 of 8 uM. |
| PC-20365 |
HN252
PPM1B inhibitor
|
HN252 is a potent protein phosphatase 1B (PPM1B) inhibitor with Ki of 0.52 uM and IC50 of 0.76 uM, shows no inhibition against topoisomerases in vitro. |
| PC-20341 |
PHPS1 sodium
SHP2 inhibitor
|
PHPS1 sodium is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM. |
| PC-20340 |
PHPS1
SHP2 inhibitor
|
PHPS1 is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM. |
