| Cat. No. |
Product Name |
Information |
| PC-21366 |
ATUX-1215
PP2A activator
|
ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo. |
| PC-21359 |
ATUX-792
PP2A activator
|
ATUX-792 is a small molecule activator of protein phosphatase 2A (PP2A), decreases survival, proliferation, and motility of neuroblastoma in vitro and tumor growth in vivo. |
| PC-21296 |
PP5 inhibitor P053
PP5 inhibitor
|
PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity. |
| PC-21074 |
PTPN22 inhibitor NC1
PTPN22 inhibitor
|
PTPN22 inhibitor NC1 is a specific, noncompetitive, allosteric PTPN22 (lymphoid-specific tyrosine phosphatase, LYP) inhibitor with Ki of 4.3 uM, effectively and specifically inhibits LYP-mediated TCR signaling in T cells. |
| PC-21043 |
NSC74429
PHLPP inhibitor
|
NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay. |
| PC-20996 |
E7/PTPN14 inhibitor compound 20
CAS 391869-70-8
|
E7/PTPN14 inhibitor compound 20 is a first-in-class inhibitor of PPI of HPV E7 oncoprotein and the cellular phosphatase PTPN14 (E7/PTPN14 interaction) with IC50 of 4.7 uM in ELISA-based assays, selectively affect the viability of HPV-positive cervical cancer cells. |
| PC-20975 |
CNBCA
SHP2 inhibitor
|
CNBCA is a selective, competitive inhibitor of Src homology phosphotyrosyl phosphatase 2 (SHP2) with IC50 of 0.87 uM, effectively suppresses breast cancer cell phenotypes. |
| PC-20969 |
Compound 182
PTP1B/PTPN2 inhibitor
|
Compound 182 is a highly potent and selective active site competitive inhibitor of PTP1B and PTPN2, inhibits the catalytic activities of PTP1B and PTPN2 with IC50 of 0.63 and 0.58 nM, respectively. |
| PC-20911 |
SHP-1 agonist SC-43
SHP-1 agonist
|
SHP-1 agonist SC-43 is a potent and orally active SHP-1 (PTPN6) agonist, SC-43 interacts with the N-SH2 domain of SHP-1 to enhance the activity of SHP-1. |
| PC-20597 |
TC-PTP inhibitor 8
TC-PTP inhibitor
|
TC-PTP inhibitor 8 is a potent, selective, cell-active inhibitor of TC-PTP inhibitor with IC50 of 9.2 nM, and Ki of 4.3 nM. |
| PC-20596 |
PTP1B-IN-2
PTP1B inhibitor
|
PTP1B-IN-2 (compound P6) is a potent, selective potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with IC50 of 50 nM, >40-fold selectivity over SHP-2 and LAR, >15-fold selectivity over the highly homologous TCPTP. |
| PC-20548 |
AQX-MN100
SHIP1 agonist
|
AQX-MN100 (ZPR-MN100) is a small-molecule agonist of SHIP1, enhances SHIP1 enzyme activity in vitro. |
