| Cat. No. |
Product Name |
Information |
| PC-42696 |
PTP1B-IN-1
PTP1B inhibitor
|
PTP1B-IN-1 is a 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for design of protein tyrosine phosphatase-1B (PTP1B) inhibitor, shows weak inhibition for PTP1B with IC50 of 1.6 mM. |
| PC-26204 |
SHP1 inhibitor M029
SHP1 inhibitor
|
SHP1 inhibitor M029 is a covalent, allosteric SHP1 inhibitor with IC50 of 2.6 uM, covalently targets cryptic Cys480 far away from the active site. |
| PC-26136 |
Pimecrolimus
Calcineurin inhibitor
|
Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with Ki of 117 nM, shows anti-inflammatory activity. |
| PC-26115 |
SHP1 agonist SCA9
SHP1 agonist
|
SHP1 agonist SCA9 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 13.4 uM. |
| PC-26016 |
ATUX-8385
PP2A activator
|
ATUX-8385 is a tricyclic sulfonamide PP2A activator, interacts PP2A scaffold subunit PR65, decreases viability, proliferation, and motility of NB cells. |
| PC-25950 |
Alexidine dihydrochloride
PTPMT1 inhibitor
|
Alexidine dihydrochloride is an anticancer agent that targets mitochondrial tyrosine phosphatase PTPMT1, induces mitochondrial apoptosis, also is a TAZ-TEAD binding inhibitor capable of suppressing TAZ-induced migration and invasion in breast cancer cells. |
| PC-25843 |
PTPN2/1 inhibitor WS35
Dual PTPN2/N1 inhibitor
|
PTPN2/1 inhibitor WS35 is potent dual PTPN2 (TCPTP) / PTPN1 inhibitor with IC50 of 5.8 /12.8 nM respectively. |
| PC-25789 |
RPT04402
PP2A molecular glue
|
RPT04402 is a PP2A molecular glue that selectively stabilizes PP2A-B56α heterotrimers. |
| PC-25663 |
L598
PTP1B/TC-PTP inhibitor
|
L598 is a potent, hosphotyrosine mimetic dual PTPN1/PTPN2 (PTP1B/TC-PTP) inhibitor with IC50 of 120 nM for both. |
| PC-25631 |
SHIP1 inhibitor A32
SHIP1 inhibitor
|
SHIP1 inhibitor A32 is a potent selective inhibitor of Src Homology 2-containing Inositol 5′-Phosphatase-1 (SHIP-1, INPP5D), shows no no inhibition of SHIP2, induces G-CSF and TPO in vivo. |
| PC-25611 |
PRLthiophenib
PRL-3 inhibitor
|
PRLthiophenib is a potent, selective inhibitor of phosphatase of regenerating liver 3 (PRL-3, PRL3) with IC50 of 7.8 uM, shows mucher weaker inhibitor for PRL-1 and -2 (IC50=31 uM and 15.8 uM), binds directly to PRL-3 with Kd of 23 uM. |
| PC-25608 |
Licoflavone A
PTP1B inhibitor
|
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B) with IC50 of 54.5 uM, also has anti-gastric cancer potency in vitro and in vivo, affects the proliferation, cycle, apoptosis, migration, invasion, and EMT by targeting VEGFR-2 and blocks the PI3K/AKT and MEK/ERK signaling pathways. |
