| Cat. No. |
Product Name |
Information |
| PC-25789 |
RPT04402
PP2A molecular glue
|
RPT04402 is a PP2A molecular glue that selectively stabilizes PP2A-B56α heterotrimers. |
| PC-25663 |
L598
PTP1B/TC-PTP inhibitor
|
L598 is a potent, hosphotyrosine mimetic dual PTPN1/PTPN2 (PTP1B/TC-PTP) inhibitor with IC50 of 120 nM for both. |
| PC-25631 |
SHIP1 inhibitor A32
SHIP1 inhibitor
|
SHIP1 inhibitor A32 is a potent selective inhibitor of Src Homology 2-containing Inositol 5′-Phosphatase-1 (SHIP-1, INPP5D), shows no no inhibition of SHIP2, induces G-CSF and TPO in vivo. |
| PC-25611 |
PRLthiophenib
PRL-3 inhibitor
|
PRLthiophenib is a potent, selective inhibitor of phosphatase of regenerating liver 3 (PRL-3, PRL3) with IC50 of 7.8 uM, shows mucher weaker inhibitor for PRL-1 and -2 (IC50=31 uM and 15.8 uM), binds directly to PRL-3 with Kd of 23 uM. |
| PC-25608 |
Licoflavone A
PTP1B inhibitor
|
Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B) with IC50 of 54.5 uM, also has anti-gastric cancer potency in vitro and in vivo, affects the proliferation, cycle, apoptosis, migration, invasion, and EMT by targeting VEGFR-2 and blocks the PI3K/AKT and MEK/ERK signaling pathways. |
| PC-24875 |
JUN-1111
Cdc25 inhibitor
|
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. |
| PC-24364 |
Laforin inhibitor 9c
Laforin inhibitor
|
Laforin inhibitor 9c is a highly potent, selective inhibitor of glycogen phosphatase laforin with IC50 of 4.0 nM and Ki value of 1.9 nM, >8000-fold selective over other 15 PTPs. |
| PC-23908 |
PTPN22 inhibitor IC-11
PTPN22 inhibitor
|
I-C11 is a selective, reversible inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22, LYP) with IC50 of 4.6 uM. |
| PC-23638 |
PTPN22 inhibitor 8b
PTPN22 inhibitor
|
PTPN22 inhibitor 8b is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase (LYP, PTPN22) with Ki/IC50 of 110/260 nM, > 9-fold selectivity over a large panel of PTPs. |
| PC-23637 |
PTPN22 inhibitor 8b-19
PTPN22 inhibitor
|
PTPN22 inhibitor 8b-19 is a potent, selective inhibitor of protein tyrosine phosphatase non-receptor type 22 (PTPN22) with IC50 of 0.25 uM, 15.2-fold and 19.2-fold selectivity against SHP2 and PTP1B, respectively. |
| PC-23571 |
Ethoxysanguinarine
CIP2A inhibitor
|
Ethoxysanguinarine (ESG) is an effective small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and its downstream signaling molecules, c-Myc and pAkt, and induces protein phosphatase 2A (PP2A) activity. |
| PC-23570 |
CIP2A inhibitor TD52
CIP2A inhibitor
|
TD52 is a small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and p-Akt, reactivates protein phosphatase 2A. |
