| Cat. No. |
Product Name |
Information |
| PC-28290 |
Agrimol B
SIRT1 modulator
|
Agrimol B is a polyphenol derived from Agrimonia pilosa Ledeb., significantly induces cytoplasm-to-nucleus shuttle of SIRT1, inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression, blocks adipogenesis at the early stage of differentiation with IC50 of 3.35 uM. |
| PC-25602 |
MC3215
SIRT5 agonist
|
MC3215 (MC-3215) is a specific, cellular active small molecule activator of mitochondrial SIRT5 with binding KD of 28 uM, increases in vitro Sirt5 deacetylase activity and elicits similar effects to Sirt5 overexpression. |
| PC-25567 |
SIRT3 activator SZC-6
SIRT3 activator
|
SIRT3 activator SZC-6 is a selective small molecule SIRT3 activator, increases SIRT3 deacetylation activitywith EC50 of 23.2 uM, binds directly to SIRT3 with SPR KD of 15 uM. |
| PC-25052 |
Forvisirvat
SIRT6 activator
|
Forvisirvat (SP-624) is a selective, orally active sirtuin 6 (SIRT6) activator with EC150 of 1.2 uM. |
| PC-24533 |
DDL-218
SirT1 enhancer
|
DDL-218 is an orally brain-permeable small-molecule sirtuin 1 (SirT1) enhancer, increases SirT1 protein levels in ApoE4-expressing N2a (N2a-E4) murine neuroblastoma cells. |
| PC-23527 |
Resveratrol
SIRT1 activator
|
Resveratrol (trans-Resveratrol; SRT501) is a specific SIRT1 and Nrf2 activator, possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties, targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase, also inhibits NQO2 (NRH: quinone oxidoreductase). |
| PC-22377 |
3-TYP
SIRT3 inhibitor
|
3-TYP is a specfiic small molecule inhibitor of Sirtuin 3 (SIRT3) with IC50 of 38 uM, selectively inhibits Sirt3 over Sirt1 and Sirt2 and is more potent than nicotinamide. |
| PC-22371 |
Honokiol
SIRT3 activator
|
Honokiol (NSC 293100) is a natural biphenolic compound derived from the bark of magnolia trees, directly binds to SIRT3 and is an effective activator of deacetylase SIRT3, shows anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective properties. |
| PC-21990 |
SIRT6 inhibitor 11e
SIRT6 inhibitor
|
SIRT6 inhibitor 11e (Compound 11e) is a potent, selective and allosteric SIRT6 inhibitor with IC50 of 0.98 uM, directly binds to SIRT6 with Kd of 9.46 uM, inhibits pancreatic cancer metastasis in vitro and vivo. |
| PC-21902 |
SRT1720 hydrochloride
SIRT1 activator
|
SRT1720 hydrochloride is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM. |
| PC-21901 |
Sirtinol
Sirtuin inhibitor
|
Sirtinol is a small molecule sirtuin (SIRT) inhibitor with IC50 of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT1 and hSIRT2, respectively. |
| PC-21890 |
SIRT6 inhibitor S6
SIRT6 inhibitor
|
SIRT6 inhibitor S6 (SIRT6-IN-1) is a selective SIRT6 inhibitor with IC50 of 106 nM, 114 nM and 314 nM for SIRT6, SIRT2 and SIRT1 respectively. |
