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Cat. No. Product Name Information
PC-49224

AM-0466

NaV1.7 inhibitor

AM-0464 (AM0464) is a highly potent, selective NaV1.7 inhibitor with IC50 of 21 nM, exhibits high levels of selectivity over other sodium channel isoforms (NaV1.5, IC50>30 uM).
PC-47036

QX-314 chloride

Sodium channel blocker

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels, also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
PC-38662

ABBV-318

Nav1.7/ Nav1.8 blocker

ABBV-318 is a small molecule voltage-gated sodium channel Nav1.7/ Nav1.8 blocker with IC50 of 3.8 and 2.8 uM for hNav1.7 and hNav1.8 in FRET assays, respectively.
PC-73070

XPC-6444

NaV1.6 inhibitor

XPC-6444 (XPC6444) is a potent, CNS-penetrant, isoform-selective NaV1.6 inhibitor with IC50 of 41 nM, also potently blocks NaV1.2 (IC50=125 nM).
PC-72898

BI 1265162

ENaC inhibitor

BI 1265162 is a potent ENaC inhibitor, inhibits Na+ transport with IC50 3 nM and 8 nM in M1 and NCI-H441 cells, respectively.
PC-72850

NBI-921352

NaV1.6 inhibitor

NBI-921352 (XEN901, NBI 921352) is a potent, highly selective, orally active inhibitor of NaV1.6 with IC50 of 51 nM (hNaV1.6 channel currents inhibition).
PC-72674

PRAX-562

Persistent INa inhibitor

PRAX-562 (PRAX562) is a novel persistent sodium current (INa) inhibitor, inhibits hNaV1.6 persistent INa induced by ATX-II or SCN8A mutation N1768D with IC50 of 141 and 75 nM, respectively.
PC-72192

GDC-0276

NaV1.7 inhibitor

GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM.
PC-72191

GDC-0310

NaV1.7 inhibitor

GDC-0310 (GDC 0310 ) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.8 nM (hNaV1.7), cellular sodium influx IC50 of 16 nM.
PC-72189

DS-1971a

NaV1.7 inhibitor

DS-1971a (DS1971a) is a highly potent, selective NaV1.7 inhibitor with IC50 of 22.8 nM (hNaV1.7) and 59.4 nM (mNaV1.7).
PC-38297

BI-8668

ENaC inhibitor

BI-8668 (BI 8668) is a highly potent and selective epithelial sodium channel (ENaC) inhibitor, inhibits Na+ current with IC50 of 17 nM (Ussing chamber assay).
PC-35155

PF-05661014

PF-05661014 is a potent, selective Nav1.3 inhibitor with IC50 of 0.26 uM, shows no activity for Nav1.7 (IC50>10 uM).

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