Cat. No. |
Product Name |
Information |
PC-20791 |
3-MB-PP1
ZAP-70 inhibitor
|
3-MB-PP1 is specific inhibitor of analogue-sensitive ZAP70 (ZAP-70(AS)), does not affect Lck or Tec kinase activity, specifically targets ZAP-70AS-dependent events. |
PC-73445 |
Sovleplenib
Syk inhibitor
|
Sovleplenib (HMPL-523) is a highly potent, selective, orally available SYK inhibitor with IC50 of 25 nM, demonstrates anti-tumor activity in B cell lymphomas. |
PC-73180 |
Entospletinib
Syk inhibitor
|
Entospletinib (GS-9973) is a potent, selective and orally bioavailable Syk kinase inhibitor with IC50 of 7.7 nM. |
PC-72472 |
RDN009
ZAP-70 inhibitor
|
RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM. |
PC-38196 |
SRX3207
Syk/PI3K inhibitor
|
SRX3207 (SRX-3207) is a potent, orally active dual Syk/PI3K inhibitor with IC50 of 39.9/244/388 nM for Syk/PI3Kα/PI3Kδ, respectively. |
PC-38018 |
ZAP 180013
Zap70 inhibitor
|
ZAP 180013 is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay). |
PC-43348 |
Fostamatinib
SYK inhibitor
|
Fostamatinib (R788 disodium salt) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM. |
PC-42880 |
R406
SYK inhibitor
|
R406 is a potent, specific and orally available Syk kinase inhibitor with Ic50 of 41 nM, inhibits anti-IgE-mediated CHMC degranulation with EC50 of 56 nM. |
PC-63126 |
ASN-002
|
ASN-002 (Gusacitinib, ASN002) is a novel and potent dual inhibitor of SYK/JAK kinases with IC50 of 5-46 nM in biochemical assays. |
PC-61380 |
Lanraplenib
Syk inhibitor
|
Lanraplenib (GS-9876, GS9876) is a potent, selective, orally active Syk kinase inhibitor with IC50 of 9.5 nM. |
PC-61366 |
Cevidoplenib
|
Cevidoplenib is a potent, selective Syk kinase inhibitor for treatment of kinase-mediated diseases.. |
PC-70329 |
BI1002494
|
BI1002494 (BI-1002494) is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin). |