Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-20097	GSK030 Antimalarial	GSK030 (GSK3212030A) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites.
PC-20095	GSK147 Antimalarial	GSK147 (GSK-147) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites (Pf IC50=40 nM).
PC-20094	GSK692 Antimalarial	GSK692 (GSK-692) is an antimalarial compound that targets blood-stage activity of the Plasmodium falciparum and Plasmodium vivax parasites (Pf IC50=10 nM).
PC-20081	OTB-658 Antibiotic	OTB-658 (OTB658) is a novel oxazolidinone anti-tuberculosis agent, shows potent antibacterial activity against Mycobacterium tuberculosis, especially multi-drug resistant tuberculosis (MDR-TB) in vitro and in vivo.
PC-20080	NTB-3119 Antibiotic	NTB-3119 (NTB3119) is a novel benzothiopyranone derivative and anti-tuberculosis agent with potent in vitro activity against both drug-susceptible and drug-resistant tuberculosis clinical strains.
PC-20079	JSF-3285 KasA inhibitor	JSF-3285 (JSF3285) is a potent small molecule inhibitor of the M. tuberculosis β-ketoacyl synthase KasA with Kd of 70.7 nM in MST assays, shows activity against H37Rv strain with MIC 0.2 uM.
PC-20076	Torezolid phosphate Antibiotic	Torezolid phosphate (DR-701, DA-7218) is the pro-drug of Tedizolid (TR-700, DA-7157), could be hydrolysed via phosphatase to form its active metabolite Tedizolid, shows good activity against several Gram positive bacteria, including Nocardia and Mycobacterium.
PC-20075	Tedizolid Antibiotic	Tedizolid (TR-700, DA-7157) is an oxazolidinone antibiotic with activity against mycobacterium tuberculosis and nocardia brasiliensis with MIC50 of 0.25 ug/mL.
PC-20074	Radezolid Antibiotic	Radezolid (RX-1741) is a biaryloxazolidinone antibiotic with improved activity, including against linezolid-resistant strains, demonstrates potency against Gram-positive bacteria including methicillin-resistant Staph. aureus and vancomycin-resistant enterococci.
PC-20073	TBI-223 Antibiotic	TBI-223 is an oxazolidinone with excellent oral bioavailability and activity against Gram-positive bacteria, works as protein synthesis inhibitor, targets an early step involving the binding of N-formylmethionyl-tRNA to the ribosome.
PC-20072	TBI-166 Antibiotic	TBI-166 is a potential next-generation antituberculosis riminophenazine with activity against Mycobacterium tuberculosis (0.063 μg/ml).
PC-20071	Posizolid Antibiotic	Posizolid (AZD2563) is an oxazolidinone antibiotic with activity against staphylococci, pneumococci and enterococci (MIC, 0.25-2 ug/mL), AZD2563 is equally active against the surveillance isolates.

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