| Cat. No. |
Product Name |
Information |
| PC-42048 |
Faropenem daloxate
Beta-lactam antibiotic
|
Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic. |
| PC-42714 |
Pretomanid
Mtb inhibitor
|
Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid. |
| PC-25448 |
KKL-1005
Antibacterial, trans-translation inhibitor
|
KKL-1005 is an anti-tubercular triazole-based molecule, binds to ribosomal protein bL12 (MST Kd=8 uM, purified E. coli bL12) and specifically inhibits the trans-translation ribosome rescue pathway, inhibits trans-translation in E. coli cells with IC50 of <1.5 uM in E. coli expressing mCherry-trpAt. |
| PC-25364 |
IMP-2380
NorA inhibitor
|
IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay. |
| PC-25351 |
ACP1-06
ClpP activator
|
ACP1-06 (ACP1b) is a small molecule activator of bacterial ClpP with EC50 of 0.3 μM and 0.7 μM for NmClpP and EcClpP respectively, binds to ClpP H sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease. |
| PC-25350 |
ACP1-01
ClpP activator
|
ACP1-01 is a small molecule activator of bacterial ClpP with EC50 of 3.4 μM and 2.6 μM for NmClpP and EcClpP respectively, noncovalently binds to ClpP C sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease. |
| PC-25341 |
IITR00803
Antibacterial
|
IITR00803 is a specific, broad-spectrum, antibacterial small-molecule with MIC of 4-16 ug/mL against enteric pathogens such as Salmonella spp., Shigella flexneri, and E. coli. |
| PC-25324 |
LPC-058
LpxC inhibitor
|
LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens. |
| PC-25241 |
Ganfeborole hydrochloride
Mtb LeuRS inhibitor
|
Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM. |
| PC-25240 |
DDD02049209
Mtb LysRS inhibitor
|
DDD02049209 is a potent, specific inhibitor of M. tuberculosis lysyl-tRNA synthetase (LysRS) with IC50 of 0.05 uM, inhibits M. tuberculosis phenotypic growth in culture (MIC) with 0.08 uM. |
| PC-25226 |
Polymyxin B
Antibiotic
|
Polymyxin B is an antibiotic that inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity, neutralizes the effect of endotoxin and induces bacterial death by increasing its permeability. |
| PC-25221 |
CMX410
Mtb Pks13 inhibitor
|
CMX410 (CMX-410) is a potent, specific, irreversible inhibitor of Mycobacterium tuberculosis (Mtb) Pks13, targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis, inhibits MABA H37Rv strain with MIC90 of 39 nM and MBC of 78 nM. |
