Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-21855	Cresomycin Antibiotic	Cresomycin (CRM) is a bridged macrobicyclic antibiotic via inhibiting bacterial ribosome, shows broad efficacy of CRM against clinical isolates of MDR Gram-negative pathogens differentiates the synthetic macrobicyclic class from traditional lincosamides.
PC-21823	AM4085 FmlH Lectin inhibitor	AM4085 is a potent, orally bioavailable lectin domain of FmLH antagonist with IC50 of 0.19 uM.
PC-21765	Trovafloxacin PANX1 inhibitor	Trovafloxacin is a broad-spectrum quinolone antibiotic, blocks the DNA gyrase and topoisomerase IV activity, also is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with IC50 of 4 uM for PANX1 inward current.
PC-21682	JSF-3269 E. faecium inhibitor	JSF-3269 is a small molecule antibacterial inhibitor against Enterococcus faecium with MIC of 1.9-3.8 uM and minimal bactericidal concentration (MBC) of 7.7-15 uM.
PC-21654	BB2-50F M. tuberculosis inhibitor	BB2-50F is a bactericidal inhibitor of M. tuberculosis with MIC value of 8 uM (H37Rv), inhibits succinate dehydrogenase and the F1Fo-ATP synthase.
PC-21549	BFA1 FixLJ inhibitor	BFA1 is a specific small-molecule activator of Burkholderia FixLJ signaling pathway, inhibit the virulence of multiple pathogenic Burkholderia species.
PC-21545	MSU-43085 Mtb MmpL3 inhibitor	MSU-43085 is a potent, orally bioavailable inhibitor of Mycobacterium tuberculosis (Mtb, EC50=120 nM) and M. abscessus survival, targets MmpL3.
PC-21529	Inhibitor 21272541 FabI inhibitor	Inhibitor 21272541 is a small molecule inhibitor against the enoyl-acyl carrier protein reductase-FabI protein of Acinetobacter baumannii.
PC-21216	C. difficile inhibitor 57 C. difficile inhibitor	C. difficile inhibitor 57 is a potent, selective, narrow-spectrum antibacterial against Clostridioides difficile with MIC50 of 0.5 ug/mL, targets cell-wall synthesis.
PC-21141	KKL-55 Bacterial EF-Tu inhibitor	KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.
PC-21137	SAV13 SaeR inhibitor	SAV13 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 1.06 uM in luciferase assays, reduces expression of hla and other virulence factors.
PC-21136	HR3744 SaeR inhibitor	HR3744 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 10 uM in saeP1 promoter assays, reduces expression of hla and other virulence factors.

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