| Cat. No. |
Product Name |
Information |
| PC-27160 |
UCP1173
DHFR inhibitor, Antifolate
|
UCP1173 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 14 nM, 190 nM, 270 nM and 91 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, potent activity against MRSA strains possessing dfrA with MIC values of 1.25 and 2.5 ug/mL. |
| PC-27136 |
SmcR inhibitor PTSP
SmcR inhibitor
|
PTSP is a specific and potent inhibitor of Vibrio LuxR/HapR proteins and LuxR homolog SmcR in Vibrio vulnificus, inhibits quorum sensing in multiple strains of V. vulnificus, V. parahaemolyticus, and V. campbellii. |
| PC-27134 |
ZN148
Metallo-β-lactamase inhibitor
|
ZN148 (APC148) is a specific, irreversible, zinc-chelating metallo-β-lactamase (MBL) inhibitor with broad activity against Ambler class B enzymes, including NDM, VIM, and IMP, restores the in vitro and in vivo activity of meropenem against multidrug-resistant MBL-producing Enterobacterales. |
| PC-27116 |
Cap5-IN-1
Bacterial Cap5 inhibitor
|
Cap5-IN-1 is a competitive, cellulo active inhibitor of bacterial cyclic oligonucleotide-based anti-phage signaling system (CBASS) effector nuclease Cap5, effectively blocks phage defenses in bacteria. |
| PC-27101 |
MP20
N. gonorrhoeae inhibitor
|
MP20 is a small molecule antibiotic effective against Neisseria gonorrhoeae with MIC of 4 ug/mL for N. gonorrhoeae ATCC 49226, shows in vitro efficacy against multidrug-resistant N. gonorrhoeae strains |
| PC-27035 |
Linezolid
Antibacterial
|
Linezolid (PNU-100766) is an oxazolidone antibiotic for staphylococcal and streptococcal infections, also has certain activity against gram-negative bacteria and anaerobes, also is a selective inhibitor of JAK2 V617F mutation but not with wild-type JAK2 protein. |
| PC-26865 |
AIP-II
AgrC inhibitor
|
AIP-II is a peptidomimetic inhibitor of staphylococcus aureus AgrC quorum sensing receptors, inhibits AgrC-III in methicillin-resistant type III Staphylococcus aureus strain AH1747 with IC50 of 0.532 nM, binds to the AgrC-II receptor and regulates virulence gene expression in Staphylococcus aureus. |
| PC-26828 |
MRL-494 hydrochloride
BamA inhibitor
|
MRL-494 hydrochloride (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA. |
| PC-26808 |
BRD1554
Mtb Pks13 inhibitor
|
BRD1554 is a selective inhibitor of Mycobacterium tuberculosis polyketide synthase 13 (Pks13). |
| PC-26780 |
Fluorothiazinone
T3SS inhibitor, Anti-virulence
|
Fluorothiazinone is a small molecule antivirulent compound that suppresses the formation of biofilms, inhibits the type III secretion system (T3SS) in Gram-negative bacteria. |
| PC-26720 |
KGDI-109
PgDPP7 inhibitor
|
KGDI-109 is the first substrate-mimetic dipeptide inhibitor of P. gingivalis dipeptidyl peptidase 7 (PgDPP7) with IC50 of 53.8 uM and Ki of 25.1 uM, exerts an inhibitory effect against P. gingivalis growth with MIC of 1.56 uM. |
| PC-26708 |
BDM91531
AcrB efflux pump inhibitor
|
BDM91531 is a potent AcrB efflux pump inhibitor, binds to the TMD of the L state and O state protomers of AcrB, exhibits potent potentiation of pyridomycin activity with EC90 of 0.24 uM. |
