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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name CAS No. Information
PC-70348

TCA-1

864941-32-2 A small molecule with activity against drug-resistant and persistent tuberculosis.
PC-70341

DSM 74

898743-92-5 A potent, orally active PfDHODH inhibitor (IC50=0.3 uM) with antimalarial activity.
PC-70340

Genz 669178

1254834-91-7 A potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
PC-70339

IDI-6273

433945-73-4 A potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.
PC-70327

Sortase-IN-6e

1809545-62-7 A small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM.
PC-70301

Negamycin

33404-78-3 A dipeptide antibiotic that inhibits the initiation of protein synthesis.
PC-61005

GSK 951A

1403602-33-4 A small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM.

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