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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name CAS No. Information
PC-61004

GSK-729

1260243-45-5 A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3.
PC-60869

NSC624548

105128-93-6 A small molecule that inhibits the activities of E. coli DNA polymerase I and calf thymus DNA polymerase alpha..
PC-70214

BRD-4592

2109805-80-1 A small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB).
PC-60475

Zoliflodacin

1620458-09-4 A novel DNA gyrase inhibitor that inhibits bacterial DNA biosynthesis, has potent in vitro activity against many different bacterial species with MIC of 0.004 to 0.25 ug/ml.
PC-60356

TAM-16

2030241-59-7 A benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13).
PC-70181

RWJ-49815

193282-45-0 A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.
PC-70093

Roseoflavin

51093-55-1 Roseoflavin is a chemical analog of FMN and riboflavin that has antimicrobial activity.

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