| Cat. No. |
Product Name |
Information |
| PC-27399 |
Amifloxacin
Antibiotic
|
Amifloxacin (WIN 49375) is an quinolone carboxylic acid antibacterial agent with MIC of 4 ug/mL against aminoglycoside-resistant Pseudomonas aeruginosa, shows broad activity for gentamicin-resistant gram-negative bacilli. |
| PC-27374 |
OSSL-632214
Mtb TrxB2 inhibitor
|
OSSL-632214 (OSSL_632214) is a potent anti-Mtb compound with MIC of 3.13-6.25 μg/mL in vitro, possibly acts by targeting Thioredoxin reductase (TrxB2, Rv3913) and inducing lipid peroxidation in Mtb. |
| PC-27279 |
Mtb IMPDH2-IN-2
Mtb IMPDH2 inhibitor
|
MtbIMPDH2-IN-2 is a potent, selective Mycobacterium tuberculosis (Mtb) inosine 5'-monophosphate dehydrogenase 2 (MtbIMPDH2) inhibitor with IC50 of 12 nM, and MIC of 12 uM for Mtb, blocks the biosynthesis of guanine nucleotides. |
| PC-27208 |
Kalamycin
METTL1 inhibitor, Antibiotic
|
Kalamycin (Kalafungin, U-19718, NSC137443) is an antibiotic, antimicrobial agent and β-lactamase inhibitor from marine Streptomyces, also is a potent inhibitor of METTL1 methyltransferase activity with IC50 of 8.9 uM, demonstrates potent antileukemia efficacy, also shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria. |
| PC-27160 |
UCP1173
DHFR inhibitor, Antifolate
|
UCP1173 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 14 nM, 190 nM, 270 nM and 91 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, potent activity against MRSA strains possessing dfrA with MIC values of 1.25 and 2.5 ug/mL. |
| PC-27136 |
SmcR inhibitor PTSP
SmcR inhibitor
|
PTSP is a specific and potent inhibitor of Vibrio LuxR/HapR proteins and LuxR homolog SmcR in Vibrio vulnificus, inhibits quorum sensing in multiple strains of V. vulnificus, V. parahaemolyticus, and V. campbellii. |
| PC-27134 |
ZN148
Metallo-β-lactamase inhibitor
|
ZN148 (APC148) is a specific, irreversible, zinc-chelating metallo-β-lactamase (MBL) inhibitor with broad activity against Ambler class B enzymes, including NDM, VIM, and IMP, restores the in vitro and in vivo activity of meropenem against multidrug-resistant MBL-producing Enterobacterales. |
| PC-27116 |
Cap5-IN-1
Bacterial Cap5 inhibitor
|
Cap5-IN-1 is a competitive, cellulo active inhibitor of bacterial cyclic oligonucleotide-based anti-phage signaling system (CBASS) effector nuclease Cap5, effectively blocks phage defenses in bacteria. |
| PC-27101 |
MP20
N. gonorrhoeae inhibitor
|
MP20 is a small molecule antibiotic effective against Neisseria gonorrhoeae with MIC of 4 ug/mL for N. gonorrhoeae ATCC 49226, shows in vitro efficacy against multidrug-resistant N. gonorrhoeae strains |
| PC-27035 |
Linezolid
Antibacterial
|
Linezolid (PNU-100766) is an oxazolidone antibiotic for staphylococcal and streptococcal infections, also has certain activity against gram-negative bacteria and anaerobes, also is a selective inhibitor of JAK2 V617F mutation but not with wild-type JAK2 protein. |
| PC-26865 |
AIP-II
AgrC inhibitor
|
AIP-II is a peptidomimetic inhibitor of staphylococcus aureus AgrC quorum sensing receptors, inhibits AgrC-III in methicillin-resistant type III Staphylococcus aureus strain AH1747 with IC50 of 0.532 nM, binds to the AgrC-II receptor and regulates virulence gene expression in Staphylococcus aureus. |
| PC-26828 |
MRL-494 hydrochloride
BamA inhibitor
|
MRL-494 hydrochloride (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA. |
