| Cat. No. |
Product Name |
Information |
| PC-26175 |
CBR64
Bacterial RNA polymerase
|
CBR64 is a specific small molecule bacterial RNA polymerase (RNAP) inhibitor, inhibits catalytic activities of RNAP but not translocation of RNA or DNA, inhibits nucleotide addition. |
| PC-26174 |
CBR703
Bacterial RNA polymerase
|
CBR703 (C0340703) is a specific small molecule bacterial RNA polymerase (RNAP) inhibitor, inhibits catalytic activities of RNAP but not translocation of RNA or DNA, inhibits nucleotide addition. |
| PC-26173 |
AAP-SO2
Mtb RNAP inhibitor
|
AAP-SO2 is highly potent Mycobacterium tuberculosis (Mtb) RNA polymerase (RNAP) inhibitor with IC50 of 25 nM using an aptamer-based in vitro transcription assay, inhibits nucleotide addition, thereby reducing elongation and increasing termination rates. |
| PC-26172 |
MMV688845
M. abscessus inhibitor
|
MMV688845 ((R)-GSK1729177A) is a small molecule inhibitor of M. abscessus complex with MIC90 of 5-10 uM for various M. abscessus strains in vitro, targets the RpoB subunit of RNA polymerase, also shows anti-M. tuberculosis. |
| PC-26097 |
CAI0019
E. faecium carbonic anhydrase inhibitor
|
CAI0019 (CAI-0019) is a potent, selective bacterial carbonic anhydrase (CA) inhibitor with Ki of 66.9 nM and 346 nM for E. faecium α-CA and E. faecium γ-CA. |
| PC-26096 |
C607-0736
V. cholerae OmpV inhibitor
|
C607-0736 is a specific small molecule inhibitor of outer membrane protein V (OmpV) withSPR KD of 0.15 uM, disrupts the virulence functions of V. cholerae OmpV. |
| PC-25987 |
MK-7762
Antitubercular
|
MK-7762 (TBD09) is a new broadly active oxazolidinone Mycobacterium tuberculosis (Mtb) inhibitor with MIC95 of 0.93 uM, inhibits the mycobacterial ribosome. |
| PC-25967 |
MK-7602
Mtb inhibitor
|
MK-7602 is a potent multi-stage dual-targeting antimalarial compound, is a dual inhibitor of plasmepsins IX and X with Ki of 0.132 nM and 0.683 nM for PfPMX and PfPMIX respectively, inhibits inhibit asexual growth of P. falciparum with EC50 of 0.4 nM. |
| PC-25839 |
(S)-(-)-Acidomycin
BioB inhibitor
|
(S)-(-)-Acidomycin is a promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis strains with MICs of 0.096-6.2 uM, inhibits biotin synthesis with a Ki of approximately 1 μM through the competitive inhibition of biotin synthase (BioB). |
| PC-25838 |
Mycobacidin
BioB inhibitor
|
Mycobacidin (Acidomycin, Actithiazic acid) is a promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis strains with MICs of 0.096-6.2 uM, inhibits biotin synthesis with a Ki of approximately 1 μM through the competitive inhibition of biotin synthase (BioB). |
| PC-25837 |
Amiclenomycin
BioA inhibitor
|
Amiclenomycin is a natural L-amino acid antibiotic that blocks the biosynthesis of biotin by inhibiting 7,8-diaminopelargonic acid synthase (BioA synthase, DAPAS), inhibits growth of microorganisms and is specific against mycobacteria in vitro. |
| PC-25836 |
BioA inhibitor C48
BioA inhibitor
|
BioA inhibitor C48 is a potent and selective inhibitor of bacterial aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis, with Ki of 200 pM, displays sub-micromolar MICs against Mycobacterium tuberculosis (Mtb, H37Rv MIC50=93 nM) and nontuberculous mycobacteria. |
