| Cat. No. |
Product Name |
Information |
| PC-25341 |
IITR00803
Antibacterial
|
IITR00803 is a specific, broad-spectrum, antibacterial small-molecule with MIC of 4-16 ug/mL against enteric pathogens such as Salmonella spp., Shigella flexneri, and E. coli. |
| PC-25324 |
LPC-058
LpxC inhibitor
|
LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens. |
| PC-25241 |
Ganfeborole hydrochloride
Mtb LeuRS inhibitor
|
Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM. |
| PC-25240 |
DDD02049209
Mtb LysRS inhibitor
|
DDD02049209 is a potent, specific inhibitor of M. tuberculosis lysyl-tRNA synthetase (LysRS) with IC50 of 0.05 uM, inhibits M. tuberculosis phenotypic growth in culture (MIC) with 0.08 uM. |
| PC-25226 |
Polymyxin B
Antibiotic
|
Polymyxin B is an antibiotic that inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity, neutralizes the effect of endotoxin and induces bacterial death by increasing its permeability. |
| PC-25221 |
CMX410
Mtb Pks13 inhibitor
|
CMX410 (CMX-410) is a potent, specific, irreversible inhibitor of Mycobacterium tuberculosis (Mtb) Pks13, targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis, inhibits MABA H37Rv strain with MIC90 of 39 nM and MBC of 78 nM. |
| PC-25155 |
TXH1033
FtsZ inhibitor
|
TXH1033 is the orally active, carboxamide prodrug of TXH9179, which is a next-generation benzamide-based FtsZ inhibitor, TXH1033 is rapidly hydrolyzed to TXH9179 by serum acetylcholinesterases, exhibited in vivo efficacyin mouse model of systemic (peritonitis) MRSA infection. |
| PC-25154 |
TXH9179
FtsZ inhibitor
|
TXH9179 is a next-generation benzamide-based FtsZ inhibitor, exhibits braod antibacterial activity against Clinical Isolates of MSSA, MRSA, VISA, VRSA, and LRSA with MIC of 0.25-0.5 ug/mL. |
| PC-25152 |
UCM53
FtsZ inhibitor
|
UCM53 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 1.3 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 13 uM. |
| PC-25151 |
UCM05
FtsZ inhibitor
|
UCM05 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 43 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 100 uM, also is a fatty acid synthase (FASN) inhibitor wiht activity against HER2+ breast cancer. |
| PC-25079 |
Bacterial SPase inhibitor MD3
LepB inhibitor
|
Bacterial SPase inhibitor MD3 a small molecule inhibitor of bacterial type I signal peptidases (SPases) with IC50 of 10 uM against P. aeruginosa LepB protein. |
| PC-25078 |
Pezulepistat
LepB inhibitor
|
Pezulepistat (Compound II) is a potent, selective inhibitor of bacterial type 1 signal peptidase LepB, shows serum MIC value of 0.5 μM against E. coli 25922, exhibits broad spectrum antibiotic activity. |
