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Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-21545

MSU-43085

Mtb MmpL3 inhibitor

MSU-43085 is a potent, orally bioavailable inhibitor of Mycobacterium tuberculosis (Mtb, EC50=120 nM) and M. abscessus survival, targets MmpL3.
PC-21529

Inhibitor 21272541

FabI inhibitor

Inhibitor 21272541 is a small molecule inhibitor against the enoyl-acyl carrier protein reductase-FabI protein of Acinetobacter baumannii.
PC-21349

EPM35

Bacterial efflux pump modulator

EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load.
PC-21216

C. difficile inhibitor 57

C. difficile inhibitor

C. difficile inhibitor 57 is a potent, selective, narrow-spectrum antibacterial against Clostridioides difficile with MIC50 of 0.5 ug/mL, targets cell-wall synthesis.
PC-21141

KKL-55

Bacterial EF-Tu inhibitor

KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.
PC-21137

SAV13

SaeR inhibitor

SAV13 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 1.06 uM in luciferase assays, reduces expression of hla and other virulence factors.
PC-21136

HR3744

SaeR inhibitor

HR3744 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 10 uM in saeP1 promoter assays, reduces expression of hla and other virulence factors.
PC-21120

Compound 5-6

FtsW inhibitor

Compound 5-6 (FtsW inhibitor 5-6) is a specific small molecule inhibitor of bacterial cell wall polymerase FtsW, competes with Lipid II for binding to FtsW with Ki of 0.8 uM, has an MIC of 1 μg /mL against S. aureus.
PC-21050

Clovibactin

Antibiotic

Clovibactin is a novel depsipeptide antibiotic, exhibits antibacterial activity against a broad range of Gram-positive pathogens (MIC, 1-2 ug/mL, ATCC 33591 MRSA), Clovibactin targets cell wall biosynthesis.
PC-21019

LPC-233

LpxC inhibitor

LPC-233 (LPC233) is a highly potent and specific inhibitor of UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC (Ki=8.9 pM), specifically inhibits lipid A synthesis and displays outstanding antibiotic activities.
PC-20990

ND-011992

Cyt‐bd inhibitor

ND-011992 is a cytochrome bd oxidase (Cyt‐bd) inhibitor, inhibits Mycobacterium tuberculosis respiratory complex I with IC50 of 0.12 uM, targets respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases.
PC-20706

ETX2514

Beta-lactamase inhibitor

Durlobactam (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.

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