| Cat. No. |
Product Name |
Information |
| PC-22717 |
PQD-1
DHFR inhibitor
|
PQD-1 is a DHFR inhibitor with activity against Mycobacterium tuberculosis, PQD-1 synergizes with the dihydropteroate synthase (DHPS) inhibitor sulfamethoxazole (SMX). |
| PC-22699 |
C10-AMS
AasS inhibitor
|
C10-AMS is an acyl adenylate mimic and acyl-acyl carrier protein synthetase (AasS, acyl-ACP synthetase) inhibitor with Ki of 0.6 uM, inhibit the AasS-catalyzed loading of fatty acids onto acyl carrier protein (ACP). |
| PC-22691 |
Trypyricin 1
Antibacterial
|
Trypyricin 1 is a broad-spectrum antibacterial with MIC of 0.5 ug/mL for S. aureus MRSA252 (MRSA), membrane fluidizer, re-sensitizes methicillin-resistant MRSA to β-lactam antibiotics both in vitro and in mice. |
| PC-22663 |
Trimethoprim
DHFR inhibitor
|
Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase (DHFR) inhibitor, shows acitvity against a wide range of Gram-positive and Gram-negative aerobic bacteria. |
| PC-22662 |
Brodimoprim
DHFR inhibitor
|
Brodimoprim (Ro 10-5970) is a trimethoprim analogue and orally active dihydrofolate reductase (DHFR) inhibitor, shows acitvity against a wide range of Gram-positive and Gram-negative aerobic bacteria. |
| PC-22624 |
AN2718
KPC-2 inhibitor
|
AN2718 is a small molecule inhibitor of the catalytic activity of the Klebsiella pneumoniae carbapenemase (KPC-2) enzyme with IC50 of 0.5 uM and ITC Kd of 86.3 nM, exhibit synergistic antimicrobial effect with Meropenem. |
| PC-22557 |
Ciprofloxacin
Antibiotic
|
Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor and fluoroquinolone antibiotic, induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. |
| PC-22556 |
LEI-800
Bacterial DNA gyrase inhibitor
|
LEI-800 is potent antibacterial as an allosteric bacterial topoisomerase DNA gyrase inhibitor with MIC of 3.1 uM and 6.25 uM for E. coli and K. pneumoniae respectively, inhibits the ATP-dependent supercoiling activity of recombinant E. coli DNA gyrase in a gel-based assay with IC50 of 35 nM. |
| PC-22548 |
D8-03
Francisella tularensis inhibitor
|
D8-03 is a potent inhibitor of intracellular growth of Francisella tularensis with IC50 of 15 nM in CFU assays, MIC50 value of 0.39 uM. |
| PC-22508 |
ECIN (E. coli inhibitor)
UPEC inhibitor
|
ECIN (E. coli inhibitor) is a copper-responsive small molecule inhibitor of wild-type uropathogenic Escherichia coli (UPEC) strains with IC50 of 336 ng/mL in the absence of copper, and 260 and 128 ng/mL in the presence of 25 and 250 µM copper, respectively. |
| PC-22507 |
A16B1
Salmonella PhoP/PhoQ inhibitor
|
A16B1 is a specfic, allosteric inhibitor of the PhoQ histidine kinase, selectively inhibits the activity of the Salmonella PhoP/PhoQ system, blocks Salmonella pathogenicity. |
| PC-22242 |
Pneumolysin inhibitor PB-3
Pneumolysin inhibitor
|
Pneumolysin inhibitor PB-3 is a specific small molecule inhibitor (pore-blocker) of pneumolysin (PLY), binds to Cys428 adjacent to the cholesterol recognition domain of PLY with KD of 256 nM, block the PLY-induced hemoglobin release in sheep erythrocytes with IC50 of 3.1 uM. |
