| Cat. No. |
Product Name |
Information |
| PC-28676 |
AX-35
QcrB inhibitor, Cyt bc1 inhibitor
|
AX-35 (GW861072X) is a potent M. tuberculosis inhibitor targeting the QcrB subunit of the cytochrome bc1 oxidase, has MIC of 0.05 ug/ml against M. tuberculosis H37Rv and 0.1 ug/mL for M. tuberculosis H37Rv-infected THP-1 macrophages. |
| PC-28666 |
MreB inhibitor A22 hydrochloride
MreB inhibitor
|
MreB inhibitor A22 hydrochloride is a specific small molecule inhibitor of bacterial actin MreB, binds directly to the MreB filament, altering its structure and causing a morphological change of the cell, leading to cell death. |
| PC-28665 |
MreB inhibitor A22
MreB inhibitor
|
MreB inhibitor A22 is a specific small molecule inhibitor of bacterial actin MreB, binds directly to the MreB filament, altering its structure and causing a morphological change of the cell, leading to cell death. |
| PC-28637 |
LasR inhibitor 2g
LasR inhibitor
|
LasR inhibitor 2g is a potent, small molecule inhibitor of P. aeruginosa QS hierarchy LasR, demonstrated exceptional biofilm inhibition with IC50 of 0.14 uM, binds LasR with high affinity (KD=38.97 uM), suppresses LasR-regulated virulence pathways, reduces pyocyanin production and bacterial motility, shows synergistic antibiotic enhancement activity. |
| PC-28636 |
LasR-IN-6
LasR inhibitor
|
LasR-IN-6 (Cpmpound 7d) is a potent quorum sensing (QS) system LasR inhibitor with IC50 of 0.261 uM, has MIC of 62.5 uM against P. aeruginosa PAO1, significantly suppressed key virulence factors, including protease production, biofilm formation, and motility phenotypes in P. aeruginosa. |
| PC-28635 |
LasR-IN-5
LasR inhibitor
|
LasR-IN-5 (Cpmpound 3c) is a potent quorum sensing (QS) system LasR inhibitor with IC50 of 1.37 uM, inhibits biofilm formation, pyocyanin, and rhamnolipids production in Pseudomonas aeruginosa. |
| PC-28634 |
LasR-IN-4
LasR inhibitor
|
LasR-IN-4 (Cpmpound 3d) is a potent quorum sensing (QS) system LasR inhibitor, inhibits QS by modulating the expression of virulence factors or by targeting LasR, inhibits biofilm formation, pyocyanin, and rhamnolipids production in Pseudomonas aeruginosa. |
| PC-28633 |
LasR-IN-3
LasR inhibitor
|
LasR-IN-3 (Cpmpound 7f) is a potent quorum sensing (QS) system LasR inhibitor, inhibits QS by modulating the expression of virulence factors or by targeting LasR, inhibits biofilm formation, pyocyanin, and rhamnolipids production in Pseudomonas aeruginosa. |
| PC-28632 |
XDS-23
LasI/LasR inhibitor
|
XDS-23 is a selective biofilm inhibitor with IC50 of 1.26 uM for inhibiting biofilm in P. aeruginosa PAO1, inhibits LasI/LasR System (las) and Pseudomonas Quinolone Signal System (pqs), suppresses the production of key virulence factors including elastase, pyocyanin, and extracellular polysaccharides, exhibits synergistic antibacterial activity and can enhance the efficacy of multiple antibiotics in both in vitro and in vivo. |
| PC-28631 |
LasR-IN-1
LasR inhibitor
|
LasR-IN-1 (Cpmpound 9g) is a potent quorum sensing (QS) system LasR inhibitor, inhibits QS by modulating the expression of virulence factors or by targeting LasR, shows anti-bacterial activity with MIC of 28.13 μM against P. aeruginosa. |
| PC-28617 |
Aurachin D
Mtb Cyt-bd inhibitor
|
Aurachin D is a smal molecule Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase (Cyt-bd) inhibitor, exhibits inhibitory effects against Gram-positive bacteria and fungi with IC50 value of 0.1 μM against Escherichia coli and IC50 ranging from 0.13 to 33 μM against Mycobacterium tuberculosis, blocks the electron transfer process, disrupts the respiratory chain and energy metabolism of pathogens. |
| PC-28610 |
Minocycline
Antibiotic
|
Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects, inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, also is a hypoxia-inducible factor (HIF)-1α inhibitor. |
