| Cat. No. |
Product Name |
Information |
| PC-22409 |
Lefamulin acetate
Antibiotic
|
Lefamulin (BC-3781) acetate is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer. |
| PC-22350 |
Cadazolid
Antibiotic
|
Cadazolid (ACT-179811) is a first-in-class quinoxolidinone antibiotic and a potent inhibitor of C. difficile protein synthesis with IC50 of 0.38 uM in in vitro transcription/translation assay, MIC of <0.03 ug/mL against Clostridioides difficile ATCC 700057. |
| PC-22101 |
IITR08367
Efflux pump AbaF inhibitor
|
IITR08367 is a potent efflux inhibitor against AbaF in A. baumannii, inhibits efflux pumps by disrupting the proton gradient across the bacterial membrane. |
| PC-21689 |
BDM91288
AcrB efflux pump inhibitor
|
BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiates the activity of a panel of antibiotics against K. pneumoniae. |
| PC-21661 |
TBAJ-5307
Non-tuberculous mycobacteria inhibitor
|
TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria (NTM) inhibitor targeting FO-domain of F1FO-ATP synthase, shows MIC50 of 4.5 nM and 6 nM against the Mab subsp. abscessus smooth strain and rough strain respectively. |
| PC-21552 |
SMT-738
LolCDE inhibitor
|
SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity. |
| PC-21546 |
SQ109
Mtb MmpL3 inhibitor
|
SQ109 (NSC 722041) is an ethambutol (EMB) analog and antitubercular agent targeting MmpL3, shows MICs of 1-0.5 uM. |
| PC-21349 |
EPM35
Bacterial efflux pump modulator
|
EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load. |
| PC-20744 |
MAC13772
BioA inhibitor
|
MAC13772 is a small molecule inhibitor of bacterial enzyme BioA with IC50 of 250 nM, the antepenultimate step in biotin biosynthesis, MAC13772 inhibits biotin biosynthesis. |
| PC-20706 |
Durlobactam sodium
Beta-lactamase inhibitor
|
Durlobactam (ETX2514) sodium is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively. |
| PC-20585 |
MAC13243
LolA inhibitor
|
MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01). |
| PC-20570 |
ML328
Bacterial AddAB complex inhibitor
|
ML328 is a first-in-class, dual inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 of 15.7 and 4.8 uM, respectively. |
