| Cat. No. |
Product Name |
Information |
| PC-49165 |
TXY541
FtsZ inhibitor
|
TXY541 is a 1-methylpiperidine-4-carboxamide prodrug of PC190723 and bacterial protein FtsZ inhibitor, TXY541 is efficacious in vivo in mouse models of systemic infection with both methicillin-sensitive and methicillin-resistant S. aureus. |
| PC-49164 |
TXA709
FtsZ inhibitor
|
TXA709 is a prodrug of FtsZ-targeting benzamide compound (TXA707) with enhanced metabolic stability, demonstrates improved pharmacokinetic properties, and superior in vivo antistaphylococcal efficacy (both oral and intravenous) relative to previously identified prodrugs (TXY436 and TXY541) of PC190723. |
| PC-49163 |
TXA6101
FtsZ inhibitor
|
TXA6101 is an FtsZ-targeting compound with activity against MRSA isolates that express either G196S or G193D mutant FtsZ proteins, shows potent in vitro antibacterial activity against MRSA clinical isolate MPW020 with MIC of 0.125 ug/mL. |
| PC-49113 |
MD-124
Antibiotic adjuvant
|
MD-124 is a potent antibiotic adjuvant against Gram-negative bacteria, sensitizes various Gram-negative bacterial species and strains, including multidrug resistant pathogens, toward existing antibiotics. |
| PC-49008 |
Fleroxacin
Antibiotic
|
Fleroxacin (AM833, Ro23-6240) is a broad-spectrum fluoroquinolone antibiotic, with activity against a variety of Gram-positive and Gram-negative bacteria with MIC90 values of 0.05 to 3.13 ug/mL. |
| PC-47040 |
Brilacidin tetrahydrochloride
Antiviral compound
|
Brilacidin (PMX-30063) is a synthetic, non-peptide, defensin-mimetic compound, exhibits broad-spectrum anti-microbial and anti-SARS-CoV-2 activities. |
| PC-47012 |
PC190723
FtsZ inhibitor
|
PC190723 is a small molecule inhibitor of FtsZ with potent and selective anti-staphylococcal activity, inhibits FtsZ and prevents cell division. |
| PC-47011 |
DS01750413
FtsZ inhibitor
|
DS01750413 is a novel FtsZ inhibitor and new derivative of PC190723 (Cat. PC-47012), inhibits S. aureus FtsZ protein with IC50 of 2 mg/L, has an IC50 of 0.03 mg/L in cell elongation assay of B. subtilis. |
| PC-38636 |
HSGN-189
LTA biosynthesis inhibitor
|
HSGN-189 is a potent lipoteichoic acid (LTA) biosynthesis inhibitor, exhibits potent antibacterial activity against both MRSA and VRE strains with MICs of 1 ug/mL. |
| PC-38634 |
SMARt751
M.tb VirS Ligand
|
SMARt751 is a small molecule that interacts with the transcriptional regulator VirS of M. tuberculosis, up-regulates expression of the mymA operon, reverses resistance to ethionamide both in vitro and in vivo. |
| PC-38633 |
GSK2556286
M.tb inhibitor
|
GSK2556286 (GSK286) a novel inhibitor of M. tuberculosis extracellularly in the presence of cholesterol and within human macrophages, inhibits growth within human macrophages with IC50 of 70 nM (H37Rv in THP-1 cells). |
| PC-73439 |
Quabodepistat
M.tb DprE1 inhibitor
|
Quabodepistat (OPC-167832) is a highly potent antituberculosis agent with MIC of 0.00024 to 0.002 ug/mL against Mycobacterium tuberculosis, targets DprE1 (IC50=258 nM, recombinant DprE1), an essential enzyme for cell wall biosynthesis. |
