| Cat. No. |
Product Name |
Information |
| PC-25652 |
JH-LPH-50
LpxH inhibitor
|
JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031). |
| PC-25641 |
D-IX216
Mtb RNAP inhibitor
|
D-IX216 is a potent, selective Mycobacterial RNA polymerase (Mtb RNAP) with IC50 of 100 nM, slows MtbRNAP translocation in a sequence-independent manner. |
| PC-25640 |
D-AAP1
Mtb RNAP inhibitor
|
D-AAP1 is a potent, selective, stereospecific activity against Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) with IC50 of 0.4 uM, shows poor inhibition of other bacterial RNAP and human RNAP I, II, and III. |
| PC-25364 |
IMP-2380
NorA inhibitor
|
IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay. |
| PC-25324 |
LPC-058
LpxC inhibitor
|
LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens. |
| PC-25241 |
Ganfeborole hydrochloride
Mtb LeuRS inhibitor
|
Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM. |
| PC-25151 |
UCM05
FtsZ inhibitor
|
UCM05 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 43 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 100 uM, also is a fatty acid synthase (FASN) inhibitor wiht activity against HER2+ breast cancer. |
| PC-25077 |
Mtb LepB inhibitor 17af
LepB inhibitor
|
Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb. |
| PC-24831 |
ANT3310 sodium
Serine β-Lactamase inhibitor
|
ANT3310 sodium (Pilabactam) is a potent, covalent broad-spectrum serine β-Lactamase inhibitor with IC50 of 1-175 nM against a panel of serine β-Lactamases. |
| PC-24737 |
Tarocin A
TarO inhibitor
|
Tarocin A is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.18 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA. |
| PC-24403 |
HilD inhibitor C26
S. Typhimurium HilD inhibitor
|
HilD inhibitor C26 is a specific small molecule inhibitor of S. Typhimurium transcriptional regulator HilD with IC50 of 16.9 uM and binds to HilD with an apparent Kd of 30.2 uM, inhibits the secretion of SipA with IC50 of 29.2 uM. |
| PC-24388 |
MBX-4132
Trans-translation inhibitor
|
MBX-4132 is a trans-translation inhibitor with IC50 of 0.6 uM and 0.4 uM in E. coli luciferase reporter assay and in vitro reconstituted assays respectively, exhibits potent broad-spectrum antibiotic activity against Gram-positive species and many Gram-negative species. |
