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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name CAS No. Information
PC-72693

EC-11716

1235486-15-3 EC-11716 (EC/11716) is a novel mycobacterium tuberculosis gyrase inhibitor with potent anti-tubercular activity (MIC 0.38 uM, M. tuberculosis H37Rv).
PC-72571

Mtb CoaBC inhibitor 1f

Mtb CoaBC inhibitor 1f is a direct small molecule inhibitor of Mtb 4'-phosphopantothenoyl-l-cysteine synthetase (PPCS, CoaB) domain of the bifunctional Mtb CoaBC (IC50=15.6 uM).
PC-72522

ETX0462

2233569-54-3 ETX0462 (ETX-0462) is a novel antibiotic with broad-spectrum activity for drug-resistant infections, inhibits Pseudomonas aeruginosa PAO1 with MIC of 0.5 mg/mL.
PC-72489

LolCDE inhibitor compound 2A

2748443-01-6 LolCDE inhibitor compound 2A is a small molecule inhibitor that inhibits the growth of P. aeruginosa by interfering with the function of the lipoprotein transport components LolCDE complex.
PC-72426

MAC-545496

838810-96-1 MAC-545496 (MAC545496) is an antivirulence compound that reverses β-lactam resistance in the community-acquired MRSA USA300 strain via inhibition on GraR function (Kd<0.1 nM).
PC-72420

KYT-1

241825-16-1 KYT-1 is a potent, selective inhibitor of P. gingivalis virulence factor Arg-gingipain (Rgp) with Ki 40 nM (RgpA/B).
PC-72419

KYT-36

454473-31-5 KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.

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