| Cat. No. |
Product Name |
Information |
| PC-73226 |
SMARCA-PB1 inhibitor 22
BRM/BRG1 inhibitor
|
SMARCA-PB1 inhibitor 22 is a potent, selective pan-SMARCA/PB1 bromodomain inhibitor with Kd of 35, 36 and 13 nM for SMARCA2 (BRM), SMARCA4 (BRG1) and PB1 (5), respectively. |
| PC-73089 |
iP300w
p300/CBP inhibitor
|
iP300w is a potent p300/CBP inhibitor, inhibits p300-mediated H3K9 acetylation with IC50 of 33 nM in HTRF assay. |
| PC-73041 |
ZL0580
BRD4 inhibitor
|
ZL0580 (ZL-0580) is a small molecule that induces epigenetic suppression of HIV via BRD4, suppresses PMA-induced HIV activation. |
| PC-72866 |
CRCM5484
BET-BD2 inhibitor
|
CRCM5484 is a potent, BET BDII-selective inhibitor with IC50 of 130/20/71 nM for BRD4-BD2/BRD3-BD2/BRD2-BD2, respectively. |
| PC-72821 |
XP-524
BET/EP300 inhibitor
|
XP-524 (XL-223, XP524) is a potent, dual-BET/EP300 inhibitor, inhibits BRD4-BD (IC50=5.8 nM) and BRD4-BD2 (IC50=1.5 nM), binds strongly to and inhibits EP300 and CBP proteins with IC50 of 28 and 116 nM, respectively. |
| PC-72789 |
NVS-BPTF-1
BPTF bromodomain inhibitor
|
NVS-BPTF-1 is the first highly potent and selective BPTF-bromodomain inhibitor with IC50 of 56 nM in an AlphaScreen assay and Kd of 71 nM in a BLI assay. |
| PC-72706 |
LM146
PB1 bromodomain inhibitor
|
LM146 (LM-146) is a potent and selective inhibitor of pan-PB1 bromodomains (Polybromo-1 protein, PBRM1 or BAF180), binds to PB1(2), PB1(5), and SMARCA2B with KD values of 110, 61, and 2100 nM, respectively. |
| PC-72676 |
UM-002
BRD4 inhibitor
|
UM-002 is a highly potent, selective, brain penetrant BRD4 bromodomain inhibitor with IC50 of 8.8 and 2.4 nM for BRD4-1 and BRD4-2, respectively. |
| PC-72646 |
I-BET567
pan-BET inhibitor
|
I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT. |
| PC-72573 |
SR-0813
ENL/AF9 YEATS inhibitor
|
SR-0813 (SR0813) is a potent, selective, dual ENL/AF9 YEATS domain inhibitor (IC50 =25/311 nM). |
| PC-72321 |
BRD8 inhibitor DN02
BRD8 inhibitor
|
BRD8 inhibitor DN02 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 48 nM, and Kd of 34 nM, displays IC50 of 0.64 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300 (IC50>10 uM). |
| PC-72187 |
SJ432
BET BD2 inhibitor
|
SJ432 (SJ-432) is a potent, highly selective BET BD2 inhibitor with Kd of 6/2 nM (BRD2-BD2/BRD4-BD2), displays 80/152-fold selectivity over BD1, respectively. |
