| Cat. No. |
Product Name |
Information |
| PC-28602 |
PTPRO-IN-1
PTPRO inhibitor
|
PTPRO-IN-1 (Compound 30k) is a potent and selective inhibitor of protein tyrosine phosphatase receptor type O (PTPRO) with IC50 of 0.16 uM, suppresses IL-6 via NF-κB pathway modulation in macrophages. |
| PC-28559 |
DI-03
PTP1B/TCPTP inhibitor
|
DI-03 is a potent, selective, reversible and competitive dual inhibitor of PTP1B and TC-PTP with IC50 of 4.7 nM and 7.1 nM respectively. |
| PC-27630 |
I-0436650
SHP2 inhibitor
|
I-0436650 is a potent, selective and allosteric inhibitor of human wild-type (wt) SHP2 with nanomolar potency, strongly inhibits ERK phosphorylation, exhibits antiproliferative activity in EGFR- and RAS-dependent cell lines. |
| PC-27292 |
DDO-4279
PP5 degrader
|
DDO-4279 is a selective serine/threonine phosphatase PP5 degrader with DC50 of 6.9 uM, selectively degrades PP5 via the ubiquitin-proteasome pathway, thereby downregulating PP5 substrate proteins PPARγ and GR. |
| PC-27280 |
Ertiprotafib
PTP1B inhibitor, IKKβ inhibitor
|
Ertiprotafib is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 1.4 uM, also is a potent inhibitor of IkappaB kinase beta (IKK-beta, IKK-β) with IC50 of 400 nM. |
| PC-26114 |
SHP1 agonist SCA1
SHP1 agonist
|
SHP1 agonist SCA1 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 36.4 uM. |
| PC-25663 |
L598
PTPN1/PTPN2 inhibitor
|
L598 is a potent, hosphotyrosine mimetic dual PTPN1/PTPN2 (PTP1B/TC-PTP) inhibitor with IC50 of 120 nM for both. |
| PC-25631 |
SHIP1 inhibitor A32
SHIP1 inhibitor
|
SHIP1 inhibitor A32 is a potent selective inhibitor of Src Homology 2-containing Inositol 5′-Phosphatase-1 (SHIP-1, INPP5D), shows no no inhibition of SHIP2, induces G-CSF and TPO in vivo. |
| PC-24886 |
Z218484536
PSPH inhibitor
|
Z218484536 is a potent and specific phosphoserine phosphatase (PSPH) inhibitor, inhibits the release of L-serine from cultured astrocytes with IC50 of 0.4 uM, reduces cellular L-serine levels with IC50 of 0.38 uM. |
| PC-24851 |
OncoACP3
ACP3 ligand
|
OncoACP3 (ProX1-(SS)) is a specific small ligand of prostatic acid phosphatase (ACP3, ACPP, PAP, PAcP) with picomolar binding affinity, shows high selectivity over placental alkaline phosphatase, TNAP and human and murine serum albumins. |
| PC-24296 |
BRD6257
PPM1D inhibitor
|
BRD6257 is a potent, selective serine/threonine phosphatase PPM1D (Wip1, PP2Cδ) inhibitor with IC50 of 5 nM in LC-MS p38 MAPK assays. |
| PC-23264 |
SP3-12
SHIP-1 inhibitor
|
SP3-12 is a novel selective small molecule inhibitor of Src Homology 2-containing Inositol 5'-Phosphatase-1 (SHIP-1, encoded by INPP5D) with IC50 of 6.1 uM and Ki of 3.2 µM, 7-fold selectivity over SHIP-2. |
