| Cat. No. |
Product Name |
Information |
| PC-28018 |
TRPV2 activator AV2-1
TRPV2 agonist
|
TRPV2 activator AV2-1 is a potent, selective TRPV2 activator, activates mTRPV2 (EC50=13.6 μM), hTRPV2 (EC50=51.8 μM) and rat TRPV2 (rTRPV2; EC50=36.3 μM). |
| PC-28017 |
Probenecid
TRPV2 agonist
|
Probenecid is a potent and specific activator of transient receptor potential vanilloid 2 (TRPV2) channel with EC50 of 31.9 uM, shows no activity against TRPV1, TRPV3, TRPV4, TRPM8 and TRPA1 channels. |
| PC-28016 |
10-Shogaol
TRPV1 agonist, COX-2 inhibitor
|
10-Shogaol ([10]-Shogaol) is an active component of steamed ginger increases adrenaline secretion via the activation of TRPV1, also partially activates 5-HT1A receptor with Ki of 3-20 uM, also inhibits PMA-stimulated MDA-MB-231 cell invasion by reducing MMP-9 expression, also inhibits COX-2 with IC50 of 7.5 uM. |
| PC-27959 |
Zucapsaicin
TRPV1 agonist
|
Zucapsaicin (Civamide, (Z)-Capsaicin) is the cis isomer of Capsaicin and orally active TRPV1 agonist, has shown therapeutic efficacy in pain accompanying osteoarthritis of the knee. |
| PC-27704 |
WR1-002
TRPML1 agonist
|
WR1-002 (TRPML1 agonist C8) is a potent, selective agonist of lysosomal transient receptor potential mucolipin channel 1 (TRPML1), is >10x more potent than ML-SA1. |
| PC-27645 |
KM-001
TRPV3 inhibitor
|
KM-001 is a potent, specific TRPV3 inhibitor/antagonist, suppresses 2-APB (50 μM)-induced Ca2+ influx in HEK-293 cells transiently transfected with hTRPV3 with IC50 of 0.26 μM. |
| PC-27644 |
Colivin
TRPV3 inhibitor
|
Colivin is a potent, selective and orally bioactive TRPV3 inhibitor/antagonist, suppresses hTRPV3 activity with IC50 of 0.23 uM in Fluorescence-based Ca2+ influx assays, inhibits hTRPV3 and mTRPV3 equally. |
| PC-27337 |
TRPV1 agonist MSP20
TRPV1 agonist
|
MSP20 is a potent, selective TRPV1 agonist with EC50 of 46 nM and Emax=78.24%, shows no agonist activity against TRPV3, TRPV4 and TRPM8 receptors. |
| PC-26845 |
JD03-02
TRPC1/5 inhibitor
|
JD03-02 is a potent, highly selective small-molecule inhibitor of TRPC1/5 heteromers with IC50 of 0.2 nM, exhibiting >10,000-fold selectivity for TRPC1/5 heteromers over TRPC5 homomers. |
| PC-26577 |
BHV-2100
TRPM3 antagonist
|
BHV-2100 (Ponometrep, BHV2100) is a selective, peripherally restricted TRPM3 antagonist, inhibits human, mouse, and rat TRPM3 with IC50 of 1-10 nM, shows >1000x selectivity vs related channels and no significant off-target liabilities. |
| PC-26421 |
JD02-174A
TRPM3 antagonist
|
JD02-174A is a highly potent, specific TRPM3 antagonist with IC50 of 0.46 nM in patch-clamp assays, shows significant analgesic efficacy. |
| PC-26388 |
Isosakuranetin
TRPM3 inhibitor
|
Isosakuranetin is a flavanone natural compound and potent specific inhibitor of TRPM3 with IC50 of 50 nM. |
