| Cat. No. |
Product Name |
Information |
| PC-72565 |
BI-749327
TRPC6 blocker
|
BI-749327 (BI 749327) is a potent, selective orally bioavailable TRPC6 antagonist (blocker) with IC50 of 13/19/15 nM for mouse/human/guinea pig TRPC6, respectively. |
| PC-72460 |
GDC-0334
TRPA1 antagonist
|
GDC-0334 (GDC0334) is a highly potent, selective, orally bioavailable TRPA1 antagonist with IC50 of 1.7 nM in cell-based assays. |
| PC-72125 |
JNJ-28583113
TRPM2 antagonist
|
JNJ-28583113 (JNJ28583113) is a potent, selective, brain penetrant TRPM2 antagonist with IC50 of 126 nM (hTRPM2). |
| PC-72123 |
AM237
TRPC5 activator
|
AM237 is a selective TRPC5 channel activator that potently activated homomeric TRPC5:C5 channels (EC50=15–20 nM in Ca2+i assays). |
| PC-72043 |
ML-SA5
Mucolipin 1 agonist
|
ML-SA5 (Mucolipin 1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM. |
| PC-35928 |
GSK1702934A
TRPC3/6 activator
|
GSK1702934A (GSK-1702934A) is a potent and selective TRPC3/6 activator with EC50 of 80/440 nM, respectively. |
| PC-35713 |
GSK3395879
TRPV4 inhibitor
|
GSK3395879 (GSK-3395879) is a novel potent, selective, orally bioavailable antagonist of TRPV4 with IC50 of 1 nM (hTRPV4). |
| PC-35235 |
AS1928370
TRPV1 inhibitor
|
AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM. |
| PC-35234 |
TRPM4 inhibitor 5
TRPM4 inhibitor, TMEM206 inhibitor
|
TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx), also inhibits TMEM206 with IC50 of 9.55 uM. |
| PC-35044 |
DS88790512
TRPC6 blocker
|
DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM). |
| PC-43289 |
ML204 hydrochloride
TRPC4/TRPC5 inhibitor
|
ML204 hydrochloride is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel. |
| PC-43288 |
ML204
TRPC4/TRPC5 inhibitor
|
ML204 is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel. |
