| Cat. No. |
Product Name |
Information |
| PC-49700 |
GRC-17536
TRPA1 inhibitor
|
GRC-17536 (GRC 17536) is a potent and selective TRPA1 antagonist, inhibits citric acid -induced Ca+2 influx with IC50 of 8.2 nM in cell-based assays. |
| PC-49696 |
BAY-390
TRPA1 inhibitor
|
BAY-390 (BAY390) is a potent, selective, brain-penetrant TRPA1 inhibitor with IC50 of 16 and 63 nM for hTRPA1 and rTRPV1, respectively. |
| PC-49684 |
JT010
TRPA1 agonist
|
JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM. |
| PC-49443 |
AMG21629
TRPV1 antagonist
|
AMG21629 is a potent and selective TRPV1 antagonist, inhibits Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 of 0.6 nM and 0.8 nM for capsaicin and acid-induced Ca2+ uptake, respectively. |
| PC-49276 |
CRCD2
NT5C2 inhibitor
|
CRCD2 is a first-in-class specific small molecule inhibitor of the cytosolic 5' nucleotidase II (NT5C2), directly binds to NT5C2 R367Q recombinant protein with KD of 70.9 uM, shows broadly activies against leukemias bearing highly prevalent relapse-associated mutant forms of NT5C2 in vitro and in vivo. |
| PC-49275 |
KS0365
TRPV3 activator
|
KS0365 (KS 0365) is a potent and selective activator of transient receptor potential vanilloid 3 (TRPV3) channel with EC50 of 5.08 uM. |
| PC-47023 |
JNc-463
TRPV4-eNOS activator
|
JNc-463 is a small-molecule that could increase the TRPV4-eNOS interaction, enhances vasodilation and exert antihypertensive effects in mice. |
| PC-38676 |
Libvatrep
TRPV1 antagonist
|
Libvatrep (SAF312) is a potent, selective non-competitive inhibitor/antagonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), shows potential for treatment of ocular surface pain. |
| PC-38603 |
Mesendogen
TRPM6 inhibitor
|
Mesendogen (Compound 6528694, MEG) is a small molecule inhibitor of TRPM6 channel, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells (hESCs) through alteration of magnesium homeostasis. |
| PC-38390 |
Evifacotrep
TRPC5 inhibitor
|
Evifacotrep is a potent selective transient receptor potential channel 5 (TRPC5) antagonist. |
| PC-38378 |
CA-008
TRPV1 agonist
|
CA-008 (Vocacapsaicin) is a non-opioid, water-soluble and injectable prodrug of capsaicin, a potent agonist of TRPV1 channel. |
| PC-73430 |
Motugivatrep
TRPV1 antagonist
|
Motugivatrep is a potent, selective transient receptor potential vanilloid 1 (TRPV1) antagonist. |
