| Cat. No. |
Product Name |
Information |
| PC-25780 |
L687
TRPC3/C6/C7 activator
|
L687 is a potent, specific TRPC3/C6/C7 activator, induces cellular antisense oligonucleotide (ASO) uptake, also induces dextran uptake and increases endocytosis. |
| PC-25774 |
Z3571
TRPC6 inhibitor
|
Z3571 is a potent, highly selective and orally bioavailable TRPC6 inhibitor with binding KD of 1.62 uM, inhibits OAG-stimulated Ca2+ influx with IC50 of 31.07 nM, shows >100-fold selectivity over TRPC3 and TRPC7. |
| PC-25552 |
TRPM2 inhibitor LC4
TRPM2 inhibitor
|
TRPM2 inhibitor LC4 is a potent and selective TRPM2 inhibitor with IC50 of 0.66 uM, reduces the infarct volume and oxidative-stress level in transient middle cerebral artery occlusion (tMCAO) model. |
| PC-25551 |
TRPM2 inhibitor D10
TRPM2 inhibitor
|
TRPM2 inhibitor D10 is a highly seletive small molecule TRPM2 inhibitor with IC50 of 2.29 uM, demonstrates significant neuroprotective effects in vitro, shows robust efficacy in reducing cerebral infarction in a transient middle cerebral artery occlusion (tMCAO) model. |
| PC-25470 |
TRPA1 agonist NMTA
TRPA1 agonist
|
TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects. |
| PC-25400 |
Br-cis-22a
TRPV6 inhibitor
|
Br-cis-22a is a brominated PCHPD analog of TRPV6 inhibitor cis-22a, inhibits uptake of Cd2+ into hTRPV6-expressing HEK 293 cells with IC50 of 0.96 uM. |
| PC-25399 |
TRPV6 inhibitor cis-22a TFA
TRPV6 inhibitor
|
TRPV6 inhibitor cis-22a TFA is a potent, selective inhibitor of TRPV6 calcium channel with IC50 of 0.32 uM, shows high selectivity against other calcium channels and related TRP targets, selectively reduces cancer cell growth on TRPV6 positive (T47D) breast cancer cells. |
| PC-25398 |
TRPV6 inhibitor cis-22a
TRPV6 inhibitor
|
TRPV6 inhibitor cis-22a is a potent, selective inhibitor of TRPV6 calcium channel with IC50 of 0.32 uM, shows high selectivity against other calcium channels and related TRP targets, selectively reduces cancer cell growth on TRPV6 positive (T47D) breast cancer cells. |
| PC-25086 |
ML2-SA2
TRPML2 agonist
|
ML2-SA2 is a selective, small-molecule TRPML2 channel agonist with EC50 of 6.4 uM, while inhibiting TRPML1 and TRPML3 with IC50 of 2.3 uM and 15.9 uM, respectively. |
| PC-25031 |
Apecotrep
TRPC6 inhibitor
|
Apecotrep (TRPC6-IN-3) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. |
| PC-24809 |
AP-18
TRPA1 inhibitor
|
AP-18 is a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 μM Cinnamaldehyde with IC50 of 3.1 uM and 4.5 μM for human and mouse TRPA1 respectively. |
| PC-24742 |
Resiniferatoxin
TRPV1 agonist
|
Resiniferatoxin ((+)-Resiniferatoxin) is a high affinity, selective agonist of transient receptor potential vanilloid 1 (TRPV1), binds HEK293/VR1 cells and CHO/VR1 cells with affinities of 84 and 103 pM, respectively. |
