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Cat. No. Product Name Information
PC-20745

LAKI

TREK channel inhibitor

LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels.
PC-20299

GIRK1/4 inhibitor 14b

GIRK1/4 inhibitor

GIRK1/4 inhibitor 14b is a potent, brain-sparing GIRK1/4 inhibitor with IC50 of 0.1 uM, exhibits excellent selectivity over GIRK1/2 channel.
PC-20298

NIP-142

Kv1.5 inhibitor

NIP-142 (NIP142) is an anti-arrhythmic agent by targeting cardiac K+ channel Kv1.5 (Kv1.5) currents, inhibits the steady-state phase with IC50 of 4.75 uM.
PC-49848

VU0546110

Sperm SLO3 channel inhibitor

VU0546110 (VU 0546110) is a potent, selective inhibitor of the sperm-specific potassium channel SLO3 with IC50 of 1.29 uM, impairs sperm function.
PC-49839

Retigabine

Kv7 opener

Retigabine (D-23129, XEN496) is an anticonvulsant compound and KV7 channel agonist (opener), enhances activation of KCNQ2/Q3 potassium channels.
PC-49796

ACOU085

KV7.4 activator

ACOU085 (ACOU 085) is a potent small-molecule agonist of Kv7.4 (KCNQ4) channel with higher potency than ML-213 in the nanomolar range.
PC-49538

SCR2682

Kv.7 activator

SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine.
PC-49468

TASK inhibitor F3

TASK Channel inhibitor

TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1).
PC-49461

C101248

THIK-1 inhibitor

C101248 is the first selective small-molecule inhibitor of tandem pore domain halothane-inhibited K+ channel 1 (THIK-1) with IC50 of 50 nM for both mouse and human THIK-1.
PC-47105

TTQC-1

BKCa activator

TTQC-1 is a potent activator of the large-conductance Ca2+-activated K+ channel (BKCa channel), directly and reversibly activates the macroscopic current of BKCa channels expressed in Xenopus oocytes from both sides of the cellular membrane, increases the maximum conductance and shifted the half activation voltage to the left with EC50 of 2.8 uM.
PC-47099

SKA-31

KCa2/KCa3.1 activator

SKA-31 is a small molecule activator of KCa2 and KCa3.1 potassium channels with EC50 values of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively.
PC-38848

KV10.1 inhibitor compound 1

Kv10.1 inhibitor

KV10.1 inhibitor compound 1 is a selective inhibitor of the voltage-gated potassium channel KV10.1 with IC50 of 740 nM.

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