| Cat. No. |
Product Name |
Information |
| PC-28699 |
APC24-7
Meropenem potentiator
|
APC24-7 is a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers, sensitizesclinical isolates of SBL- and MBL-producing Klebsiella pneumoniae and Escherichia coli to meropenem. |
| PC-28698 |
MprB-IN-1
Mtb MprB inhibitor
|
MprB-IN-1 (Compound 7a) is a small molecule inhibitor of Mycobacterium tuberculosis (Mtb) histidine kinase MprB, reduces ESX-1-dependent pathogenicity, prevents dissemination of Mtb from the lung to the spleen in mouse model of acute TB infection. |
| PC-28619 |
ETX1975-3
Mtb Cyt-bd inhibitor
|
ETX1975-3 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase (Cyt-bd) inhibitor with ATP IC50 of 1.7 uM and MIC of 5.0 uM for M. abscessus ΔqcrCAB strain. |
| PC-28618 |
HM2-16F
Mtb Cyt-bd inhibitor
|
HM2-16F is an anti-tubercular inhibitor with bactericidal properties that inhibiting cytochrome bd oxidase (Cyt-bd), inhibits the growth of bedaquiline-resistant mutants, weakly inhibits F1Fo-ATP synthase, depletes ATP, and affects the entry of acetyl-CoA into the Krebs cycle, synergizes with the cytochrome bcc-aa3 oxidase inhibitor Q203 (Telacebec). |
| PC-28616 |
YH-685
Mtb Cyt-bd inhibitor
|
YH-685 is a specific small molecule inhibitor of Mycobacterium tuberculosis (Mtb) cytochrome bd terminal oxidase (Cyt-bd), inhibits Cyt-bcc-deficient M. smegmatis with MIC of 0.8 uM, enhances TB47-mediated inhibition of planktonic and intracellular Mtb. |
| PC-28500 |
LBM-415
Peptide deformylase inhibitor
|
LBM-415 (LBM415, NVP-PDF713, VIC-104959) is a potent bacterial peptide deformylase (PDF) inhibitor, exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci with MIC90 range of 0.12-8 ug/mL. |
| PC-28359 |
DksA inhibitor Compound 916
DksA inhibitor
|
DksA inhibitor Compound 916 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 928 nM, has MIC50 of 32 ug/mL against nontyphoidal S. enterica serovar Typhimurium strain 14028s and E. coli strain W3110. |
| PC-28358 |
VKT-17-P4-23
DksA inhibitor
|
VKT-17-P4-23 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 72 nM, has MIC50 of 16 ug/mL against S. Typhimurium. |
| PC-28303 |
VMP-7
Mtb GlgE inhibitor
|
VMP-7 is a small molecule inhibitor of Mycobacterium tuberculosis (M.tb) maltosyltransferase (GlgE), a key enzyme in the α-glucan biosynthesis pathway of M.tb, exhibits significant inhibitory activity against M.tb with MIC of 15.5 ug/mL. |
| PC-28183 |
DDD00079282
Mtb GuaB inhibitor
|
DDD00079282 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki of 0.22 uM, does not inhibit human IMPDH, shows antitubercular activity against Mtb H37Rv with MIC of 2 uM. |
| PC-28182 |
Q151
GuaB2 inhibitor
|
Q151 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, MtbIMPDH2) with Ki app of 18 nM, does not inhibit human IMPDH2. |
| PC-28179 |
Mtb GuaB2 inhibitor G9
GuaB2 inhibitor
|
Mtb GuaB2 inhibitor G9 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2) with IC50 of 0.94 nM, and potent MIC against virulent Mtb H37Rv (IC50=58 nM). |
